Synthesis and Diverse Pharmacological Actions of Thiosemicarbazide Analogs: A Review

被引：0

作者：

Jindaniya, Varsha ^{[1
]}

Mishra, Rakhi ^{[1
]}

Mazumder, Avijit ^{[1
]}

Tyagi, Shivani ^{[1
]}

机构：

[1] Noida Inst Engn & Technol, Pharm Inst, Knowledge Pk-2, Plot 19, Greater Noida 201306, India

来源：

LETTERS IN DRUG DESIGN & DISCOVERY | 2024年 / 21卷 / 12期

关键词：

Synthesis; thiosemicarbazide; biological studies; discovery; diseases; bioactive substances; POTENTIAL ANTITUMOR AGENTS; BIOLOGICAL EVALUATION; IN-VITRO; CRYSTAL-STRUCTURES; DERIVATIVES; COMPLEXES; ANTIFUNGAL; ANTICANCER; SEMICARBAZIDE; ANTIBACTERIAL;

D O I：

10.2174/1570180820666230614121851

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Background Thiosemicarbazide is an important substance in the synthesis of pharmacological and bioactive substances, and it is commonly used in the discovery of new medications. Multiple synthetic approaches exist for the creation of different thiosemicarbazide analogs, which are then discovered to treat a variety of diseases.Objective This review paper aims to determine the growing importance of thiosemicarbazide analogs in various types of sickness by examining various unique synthetic methods that have been described to manufacture them.Methods To incorporate published research and review papers, a comprehensive review of the literature from many sources during the past 24 years was conducted.Results This paper summarises the findings of a literature review about the synthesis and biological activity of thiosemicarbazide and thiosemicarbazone derivatives.Conclusion Numerous new studies on the role of thiosemicarbazide and thiosemicarbazone derivatives, as well as their methods of production and biological activity for various forms of the disease, are discussed in this review article.

引用

页码：2302 / 2334

页数：33

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