Breast cancer: Prognostic value of "TN" status versus tumor gene expression profile

被引：0

作者：

Arana, Juan Antonio Mieza ^{[1
,2
]}

Estevez, Ignacio Zabalza ^{[3
,4
]}

Ruiz, Jose Antonio Lopez ^{[5
]}

Ruiz, Maria del Mar Vivanco ^{[6
]}

Maseda, Andoni Lopez ^{[5
]}

机构：

[1] Hosp Univ Cruces, Unidad Ginecol Oncol, Bizkaia, Pais Vasco, Spain

[2] Inst Ginecol Deusto Bilbao, Unidad Ginecol Oncol, Bizkaia, Pais Vasco, Spain

[3] Hosp Univ Galdakao, Serv Anat Patol, Bizkaia, Pais Vasco, Spain

[4] Hosp Zorrotzaurre, Unidad Anat Patol, Bizkaia, Pais Vasco, Spain

[5] Grp Radiol PRETEIMAGEN, Serv Radiodiagnost, Bizkaia, Pais Vasco, Spain

[6] CIC BioGUNE, Unidad Biol, Parque Tecnol Bizkaia Derio, Bizkaia, Pais Vasco, Spain

来源：

REVISTA DE SENOLOGIA Y PATOLOGIA MAMARIA | 2024年 / 37卷 / 02期

关键词：

Breast cancer; The TNM classification of malignant tumors; Prognosis; MammaPrint (R); SIGNATURE; STAGE;

D O I：

10.1016/j.senol.2024.100592

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Objectives: To analyze the prognostic value of the "TNM" system, and specifically the "TN" status, compared to the tumor gene expression profile, when evaluating the risk of metastatic disease. Materials and methods: Retrospective review of 224 cases of infiltrating breast cancer. Genomic risk was established using the 70-gene gene expression platform (MammaPrint (R)). The result obtained with the genomic risk assessment has been considered "gold standard". Results: 126 cases (56.25%) showed a "low" risk genomic profile and 98 cases (43.75%) showed a "high" risk. Among those with low genomic risk, 26.19% of tumors classified "T2", "T3" and "T4" were observed. On the contrary, among those with "high" risk, 67.35% of tumors classified as "T1" were observed. Regarding the "N" status, among the "low" risk tumors, 26.98% of cases classified as "N1", "N2" and "N3" were observed. On the other hand, among those with "high" genomic risk, 77.14% of cases classified as "N0" were observed. Among a total of 131 "T1N0" tumors, 57 (43.51%) showed "high" genomic risk. No significant differences have been observed in terms of risk assessment of metastatic disease (high vs. low) between the various "TN" categories studied. Conclusions: The evaluation of the risk of metastatic disease using the "TN" system is not accurate. The detection of early tumors does not necessarily mean a good prognosis. On the contrary, the detection of "T2" or "N1" tumors does not imply a poor prognosis in all cases.

引用

页数：6

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