Thyroid cancer usually begins with thyroid dysfunction and nodules and has become the most common cancer globally, especially in women. Although the causes of thyroid dysfunction are complex, the presence of environmental pollutants, especially certain pesticides as established mutagens, has been widely accepted. Zebrafish (Danio rerio) have similar toxic reactions and signal transduction pathways to humans and are very similar to humans in physiology, development, and metabolic function. Here, the direct toxicity effects and mechanisms of different insecticides and herbicides on zebrafish thyroid functions and indirect toxicity effects originating from thyroid dysfunction were summarized and compared. The overall toxicity of insecticides on the zebrafish thyroid was greater than that of herbicides based on effective concentrations. Penpropathrin and atrazine were more typical thyroid disruptors than other pesticides. Meanwhile, chiral pesticides showed more sophisticated single/combined toxicity effects on both parental and offspring zebrafish. Besides thyroid hormone levels and HPT axis-related gene expression alteration, developmental toxicity, immunotoxicity, and oxidative damage effects were all observed. These data are necessary for understanding the thyroid interference effect of pesticides on humans and for screening for thyroid disruptors in surface water with zebrafish models for the pre-assessment of human health risks and ecological risk control in the future.
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Jawaharlal Nehru Med Coll, Dept Med, Wardha, IndiaJawaharlal Nehru Med Coll, Dept Med, Wardha, India
Ansari, Ifthekar
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Kumar, Sunil
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Jawaharlal Nehru Med Coll, Dept Med, Wardha, IndiaJawaharlal Nehru Med Coll, Dept Med, Wardha, India
Kumar, Sunil
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Acharya, Sourya
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Jawaharlal Nehru Med Coll, Dept Med, Wardha, India
Datta Meghe Inst Med Sci, Dept Med, Wardha, IndiaJawaharlal Nehru Med Coll, Dept Med, Wardha, India
Acharya, Sourya
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Agrawal, Sachin
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Jawaharlal Nehru Med Coll, Dept Med, Wardha, India
Datta Meghe Inst Med Sci, Dept Med, Wardha, IndiaJawaharlal Nehru Med Coll, Dept Med, Wardha, India
Agrawal, Sachin
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Saboo, Keyur
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Jawaharlal Nehru Med Coll, Dept Internal Med, Wardha, IndiaJawaharlal Nehru Med Coll, Dept Med, Wardha, India
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Univ Autonoma Madrid, Consejo Super Invest Cientificas, Inst Invest Biomed, Madrid 28029, SpainUniv Autonoma Madrid, Consejo Super Invest Cientificas, Inst Invest Biomed, Madrid 28029, Spain
Bernal, J
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Guadaño-Ferraz, A
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Univ Autonoma Madrid, Consejo Super Invest Cientificas, Inst Invest Biomed, Madrid 28029, SpainUniv Autonoma Madrid, Consejo Super Invest Cientificas, Inst Invest Biomed, Madrid 28029, Spain
Guadaño-Ferraz, A
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Morte, B
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Univ Autonoma Madrid, Consejo Super Invest Cientificas, Inst Invest Biomed, Madrid 28029, SpainUniv Autonoma Madrid, Consejo Super Invest Cientificas, Inst Invest Biomed, Madrid 28029, Spain
机构:
Feevale Univ, Dept Hlth Sci, ERS 239,2755, BR-93525075 Novo Hamburgo, RS, BrazilFeevale Univ, Dept Hlth Sci, ERS 239,2755, BR-93525075 Novo Hamburgo, RS, Brazil
Bernieri, Tanandra
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Rodrigues, Dabiana
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Feevale Univ, Dept Hlth Sci, ERS 239,2755, BR-93525075 Novo Hamburgo, RS, BrazilFeevale Univ, Dept Hlth Sci, ERS 239,2755, BR-93525075 Novo Hamburgo, RS, Brazil
Rodrigues, Dabiana
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Barbosa, Isadora Randon
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Ardenghi, Patricia Grolli
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Feevale Univ, Dept Hlth Sci, ERS 239,2755, BR-93525075 Novo Hamburgo, RS, BrazilFeevale Univ, Dept Hlth Sci, ERS 239,2755, BR-93525075 Novo Hamburgo, RS, Brazil
Ardenghi, Patricia Grolli
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da Silva, Luciano Basso
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Feevale Univ, Dept Hlth Sci, ERS 239,2755, BR-93525075 Novo Hamburgo, RS, BrazilFeevale Univ, Dept Hlth Sci, ERS 239,2755, BR-93525075 Novo Hamburgo, RS, Brazil
机构:
Jawaharlal Nehru Med Coll, Dept Med, Wardha, IndiaJawaharlal Nehru Med Coll, Dept Med, Wardha, India
Ansari, Ifthekar
;
Kumar, Sunil
论文数: 0引用数: 0
h-index: 0
机构:
Jawaharlal Nehru Med Coll, Dept Med, Wardha, IndiaJawaharlal Nehru Med Coll, Dept Med, Wardha, India
Kumar, Sunil
;
Acharya, Sourya
论文数: 0引用数: 0
h-index: 0
机构:
Jawaharlal Nehru Med Coll, Dept Med, Wardha, India
Datta Meghe Inst Med Sci, Dept Med, Wardha, IndiaJawaharlal Nehru Med Coll, Dept Med, Wardha, India
Acharya, Sourya
;
Agrawal, Sachin
论文数: 0引用数: 0
h-index: 0
机构:
Jawaharlal Nehru Med Coll, Dept Med, Wardha, India
Datta Meghe Inst Med Sci, Dept Med, Wardha, IndiaJawaharlal Nehru Med Coll, Dept Med, Wardha, India
Agrawal, Sachin
;
Saboo, Keyur
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h-index: 0
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Jawaharlal Nehru Med Coll, Dept Internal Med, Wardha, IndiaJawaharlal Nehru Med Coll, Dept Med, Wardha, India
机构:
Univ Autonoma Madrid, Consejo Super Invest Cientificas, Inst Invest Biomed, Madrid 28029, SpainUniv Autonoma Madrid, Consejo Super Invest Cientificas, Inst Invest Biomed, Madrid 28029, Spain
Bernal, J
;
Guadaño-Ferraz, A
论文数: 0引用数: 0
h-index: 0
机构:
Univ Autonoma Madrid, Consejo Super Invest Cientificas, Inst Invest Biomed, Madrid 28029, SpainUniv Autonoma Madrid, Consejo Super Invest Cientificas, Inst Invest Biomed, Madrid 28029, Spain
Guadaño-Ferraz, A
;
Morte, B
论文数: 0引用数: 0
h-index: 0
机构:
Univ Autonoma Madrid, Consejo Super Invest Cientificas, Inst Invest Biomed, Madrid 28029, SpainUniv Autonoma Madrid, Consejo Super Invest Cientificas, Inst Invest Biomed, Madrid 28029, Spain
机构:
Feevale Univ, Dept Hlth Sci, ERS 239,2755, BR-93525075 Novo Hamburgo, RS, BrazilFeevale Univ, Dept Hlth Sci, ERS 239,2755, BR-93525075 Novo Hamburgo, RS, Brazil
Bernieri, Tanandra
;
Rodrigues, Dabiana
论文数: 0引用数: 0
h-index: 0
机构:
Feevale Univ, Dept Hlth Sci, ERS 239,2755, BR-93525075 Novo Hamburgo, RS, BrazilFeevale Univ, Dept Hlth Sci, ERS 239,2755, BR-93525075 Novo Hamburgo, RS, Brazil
Rodrigues, Dabiana
;
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机构:
Barbosa, Isadora Randon
;
Ardenghi, Patricia Grolli
论文数: 0引用数: 0
h-index: 0
机构:
Feevale Univ, Dept Hlth Sci, ERS 239,2755, BR-93525075 Novo Hamburgo, RS, BrazilFeevale Univ, Dept Hlth Sci, ERS 239,2755, BR-93525075 Novo Hamburgo, RS, Brazil
Ardenghi, Patricia Grolli
;
da Silva, Luciano Basso
论文数: 0引用数: 0
h-index: 0
机构:
Feevale Univ, Dept Hlth Sci, ERS 239,2755, BR-93525075 Novo Hamburgo, RS, BrazilFeevale Univ, Dept Hlth Sci, ERS 239,2755, BR-93525075 Novo Hamburgo, RS, Brazil