Effects of Insecticide and Herbicides on Thyroid Disturbances in Zebrafish

被引:1
作者
Ma, Tingting [1 ,2 ,3 ]
An, Xiangji [1 ]
Wu, Peng [4 ]
He, Xiaoli [1 ]
Luo, Yongming [2 ]
机构
[1] Hubei Univ Arts & Sci, Coll Resource Environm & Tourism, Xiangyang 441053, Peoples R China
[2] Chinese Acad Sci, Key Lab Soil & Sustainable Agr, Nanjing 211135, Peoples R China
[3] Hubei Univ Arts & Sci, Hubei Key Lab Low Dimens Optoelect Mat & Devices, Xiangyang 441053, Peoples R China
[4] Jiangsu Rainfine Environm Sci & Technol Co Ltd, Nanjing 210009, Peoples R China
基金
中国国家自然科学基金;
关键词
zebrafish; thyroid dysfunction; environmental endocrine disruptors; life stage; hypothalamic-pituitary-thyroid axis; LONG-TERM EXPOSURE; DANIO-RERIO; ENDOCRINE DISRUPTION; DEVELOPMENTAL TOXICITY; MATERNAL EXPOSURE; EYE DEVELOPMENT; REPRODUCTION; EXPRESSION; SYSTEM; LARVAE;
D O I
10.3390/toxics12080570
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
Thyroid cancer usually begins with thyroid dysfunction and nodules and has become the most common cancer globally, especially in women. Although the causes of thyroid dysfunction are complex, the presence of environmental pollutants, especially certain pesticides as established mutagens, has been widely accepted. Zebrafish (Danio rerio) have similar toxic reactions and signal transduction pathways to humans and are very similar to humans in physiology, development, and metabolic function. Here, the direct toxicity effects and mechanisms of different insecticides and herbicides on zebrafish thyroid functions and indirect toxicity effects originating from thyroid dysfunction were summarized and compared. The overall toxicity of insecticides on the zebrafish thyroid was greater than that of herbicides based on effective concentrations. Penpropathrin and atrazine were more typical thyroid disruptors than other pesticides. Meanwhile, chiral pesticides showed more sophisticated single/combined toxicity effects on both parental and offspring zebrafish. Besides thyroid hormone levels and HPT axis-related gene expression alteration, developmental toxicity, immunotoxicity, and oxidative damage effects were all observed. These data are necessary for understanding the thyroid interference effect of pesticides on humans and for screening for thyroid disruptors in surface water with zebrafish models for the pre-assessment of human health risks and ecological risk control in the future.
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页数:18
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