Radiomolecular Theranostics With Fibroblast-Activation-Protein Inhibitors and Peptides

被引：5

作者：

Baum, Richard P. ^{[1
,9
]}

Novruzov, Emil ^{[2
]}

Zhao, Tianzhi ^{[3
,4
,5
]}

Greifenstein, Lukas ^{[1
]}

Jakobsson, Vivianne ^{[3
,4
,5
]}

Perrone, Elisabetta ^{[6
]}

Mishra, Aditi ^{[1
]}

Eismant, Aleksandr ^{[1
]}

Ghai, Kriti

Klein, Ortwin ^{[7
]}

Jaeschke, Bastian ^{[7
]}

Benz-Zils, Daniel ^{[1
]}

Cardinale, Jens ^{[2
]}

Mori, Yuriko ^{[2
]}

Giesel, Frederik L. ^{[2
,8
]}

Zhang, Jingjing ^{[3
,4
,5
]}

机构：

[1] DKD HELIOS Klin, Ctr Adv Radiomol Precis Oncol, Dept Nucl Med, Curanosticum Wiesbaden Frankfurt, Wiesbaden, Germany

[2] Heinrich Heine Univ, Univ Hosp Dusseldorf, Med Fac, Dept Nucl Med, Dusseldorf, Germany

[3] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Diagnost Radiol, Singapore, Singapore

[4] Natl Univ Singapore, Clin Imaging Res Ctr, Ctr Translat Med, Yong Loo Lin Sch Med, Singapore, Singapore

[5] Natl Univ Singapore, Yong Loo Lin Sch Med, Nanomed Translat Res Program, Singapore, Singapore

[6] Univ Cattolica Sacro Cuore, Inst Nucl Med, Dept Radiol & Hematol Sci, Rome, Italy

[7] Helios DKD Klin, Dept Oncol MVZ, Wiesbaden, Germany

[8] Osaka Univ, Inst Radiat Sci, Osaka, Japan

[9] DKD HELIOS Klin Wiesbaden, Ctr Adv Radiomol Precis Oncol, Aukammallee 33, D-65191 Wiesbaden, Germany

来源：

SEMINARS IN NUCLEAR MEDICINE | 2024年 / 54卷 / 04期

关键词：

TUMOR PROGRESSION; PHASE-I; CANCER; EXPERIENCE; THERAPY; PET/CT; EXPRESSION; TRACERS; BREAST;

D O I：

10.1053/j.semnuclmed.2024.05.010

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

The advancement of theranostics, which combines therapeutic and diagnostic capabilities in oncology, has significantly impacted cancer management. This review explores fibroblast activation protein (FAP) expression in the tumor microenvironment (TME) and its association with various malignancies, highlighting its potential as a theranostic marker for PET/CT imaging using FAP-targeted tracers and for FAP-targeted radiopharmaceutical therapy. We examine the development and clinical applications of FAP inhibitors (FAPIs) and peptides, providing insights into their diagnostic accuracy, initial therapeutic efficacy, and clinical impact across diverse cancer types, as well as the synthesis of novel FAP-targeted ligands. This review aims to showcase the promising outcomes and challenges in integrating FAPtargeted approaches into cancer management. Semin Nucl Med 54:537-556 (c) 2024 Published by Elsevier Inc.

引用

页码：537 / 556

页数：20

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