Thoughts on the research of African swine fever live-attenuated vaccines

被引：3

作者：

Chu, Xuefei ^{[1
]}

Ge, Shengqiang ^{[2
,3
,4
]}

Zuo, Yuanyuan ^{[2
]}

Cui, Jin ^{[2
]}

Sha, Zhou ^{[2
]}

Han, Naijun ^{[2
]}

Wu, Bingrong ^{[1
]}

Ni, Bo ^{[2
]}

Zhang, Hui ^{[2
]}

Lv, Yan ^{[2
]}

Wang, Zhiliang ^{[2
]}

Xiao, Yihong ^{[1
]}

机构：

[1] Shandong Agr Univ, Coll Anim Sci & Technol, 61 Daizong St, Tai An 271018, Shandong Provin, Peoples R China

[2] China Anim Hlth & Epidemiol Ctr, 369 Nanjing Rd, Qingdao 266032, Peoples R China

[3] Qingdao Key Lab Modern Bioengn & Anim Dis Res, Qingdao 266032, Peoples R China

[4] Minist Agr & Rural Affairs, Key Lab Anim Biosafety Risk Warning Prevent & Cont, Qingdao 266032, Shandong, Peoples R China

来源：

VACCINE | 2024年 / 42卷 / 25期

关键词：

Live attenuated vaccine; Gene-deficient vaccine strain; Immunization; Challenge protection; Safty; ISOLATE HARBORING DELETIONS; VIRULENCE-ASSOCIATED GENE; GEORGIA ISOLATE; PORCINE MACROPHAGES; DOMESTIC PIGS; VIRUS; PROTECTION; INFECTION; 9GL; EXPRESSION;

D O I：

10.1016/j.vaccine.2024.06.020

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

African swine fever (ASF) is a contagious and fatal disease caused by the African swine fever virus (ASFV), which can infect pigs of all breeds and ages. Most infected pigs have poor prognosis, leading to substantial economic losses for the global pig industry. Therefore, it is imperative to develop a safe and efficient commercial vaccine against ASF. The development of ASF vaccine can be traced back to 1960. However, because of its large genome, numerous encoded proteins, and complex virus particle structure, currently, no effective commercial vaccine is available. Several strategies have been applied in vaccine design, some of which are potential candidates for vaccine development. This review provides a comprehensive analysis on the safety and effectiveness, suboptimal immunization effects at high doses, absence of standardized evaluation criteria, notable variations among strains of the same genotype, and the substantial impact of animal health on the protective efficacy against viral challenge. All the information will be helpful to the ASF vaccine development.

引用

页数：8

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