Evolutionary and biomedical implications of sex differences in the primate brain transcriptome

被引：4

作者：

DeCasien, Alex R. ^{[1
,2
,3
]}

Chiou, Kenneth L. ^{[4
,5
,6
,7
]}

Testard, Camille ^{[8
]}

Mercer, Arianne ^{[6
]}

Negron-Del Valle, Josue E. ^{[5
]}

Surratt, Samuel E. Bauman ^{[9
]}

Gonzalez, Olga ^{[10
]}

Stock, Michala K. ^{[11
]}

Ruiz-Lambides, Angelina V. ^{[9
]}

Martinez, Melween I. ^{[9
]}

Anton, Susan C. ^{[12
]}

Walker, Christopher S. ^{[13
]}

Sallet, Jerome ^{[14
]}

Wilson, Melissa A. ^{[4
,6
,15
]}

Brent, Lauren J. N. ^{[16
]}

Montague, Michael J. ^{[8
]}

Sherwood, Chet C. ^{[17
]}

Platt, Michael L. ^{[8
,18
,19
]}

Higham, James P. ^{[1
,2
]}

Snyder-Mackler, Noah ^{[4
,5
,6
,7
,20
]}

机构：

[1] NYU, Dept Anthropol, New York, NY 10012 USA

[2] New York Consortium Evolutionary Primatol, New York, NY 10460 USA

[3] Natl Inst Mental Hlth, Sect Dev Neurogenom, Bethesda, MD 20892 USA

[4] Arizona State Univ, Ctr Evolut & Med, Tempe, AZ 85287 USA

[5] Arizona State Univ, Sch Life Sci, Tempe, AZ 85287 USA

[6] Univ Washington, Dept Psychol, Seattle, WA 98195 USA

[7] Univ Washington, Nathan Shock Ctr Excellence Basic Biol Aging, Seattle, WA 98195 USA

[8] Univ Penn, Dept Neurosci, Philadelphia, PA USA

[9] Univ Puerto Rico, Caribbean Primate Res Ctr, San Juan, PR USA

[10] Texas Biomed Res Inst, Southwest Natl Primate Res Ctr, San Antonio, TX USA

[11] Metropolitan State Univ Denver, Dept Sociol & Anthropol, Denver, CO USA

[12] Univ Penn, Dept Psychol, Philadelphia, PA 19104 USA

[13] North Carolina State Univ, Dept Mol Biomed Sci, Coll Vet Med, Raleigh, NC USA

[14] Univ Lyon, Stem Cell & Brain Res Inst, Lyon, France

[15] Arizona State Univ, Biodesign Ctr Mech Evolut, Tempe, AZ USA

[16] Univ Exeter, Ctr Res Anim Behav, Exeter, England

[17] George Washington Univ, Dept Anthropol, Washington, DC USA

[18] Univ Penn, Dept Psychol, Philadelphia, PA USA

[19] Univ Penn, Dept Mkt, Philadelphia, PA USA

[20] Arizona State Univ, ASU Banner Neurodegenerat Dis Res Ctr, Tempe, AZ USA

来源：

CELL GENOMICS | 2024年 / 4卷 / 07期

基金：

美国国家科学基金会; 美国国家卫生研究院;

关键词：

GENE-EXPRESSION; PREFRONTAL CORTEX; MOLECULAR EVOLUTION; CELL NUMBERS; BIASED GENES; REVEALS; DISEASE; ANNOTATION; GENERATION; CONSTRAINT;

D O I：

10.1016/j.xgen.2024.100589

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Humans exhibit sex differences in the prevalence of many neurodevelopmental disorders and neurodegenerative diseases. Here, we generated one of the largest multi-brain-region bulk transcriptional datasets for the rhesus macaque and characterized sex-biased gene expression patterns to investigate the translatability of this species for sex-biased neurological conditions. We identify patterns similar to those in humans, which are associated with overlapping regulatory mechanisms, biological processes, and genes implicated in sex- biased human disorders, including autism. We also show that sex-biased genes exhibit greater genetic variance for expression and more tissue-specific expression patterns, which may facilitate rapid evolution of sex-biased genes. Our findings provide insights into the biological mechanisms underlying sex-biased disease and support the rhesus macaque model for the translational study of these conditions.

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