Menstrual Blood Stem Cells-Derived Exosomes as Promising Therapeutic Tools in Premature Ovarian Insufficiency Induced by Gonadotoxic Systemic Anticancer Treatment

被引：2

作者：

Cordeiro, Mariana Robalo ^{[1
]}

Roque, Ricardo ^{[2
]}

Laranjeiro, Barbara ^{[1
]}

Carvalhos, Carlota ^{[1
]}

Figueiredo-Dias, Margarida ^{[1
]}

机构：

[1] Univ Coimbra, Gynecol Univ Clin, Fac Med, P-3000548 Coimbra, Portugal

[2] Portuguese Inst Oncol Coimbra, Med Oncol Dept, P-3000075 Coimbra, Portugal

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2024年 / 25卷 / 15期

关键词：

extracellular vesicles; menstrual blood-derived stem cells; regenerative medicine; premature ovarian insufficiency; cancer; PLATELET-RICH PLASMA; FERTILITY; MECHANISMS; IMPACT; WOMEN;

D O I：

10.3390/ijms25158468

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Gonadotoxicity resulting from systemic and locoregional cancer treatments significantly threatens women's reproductive health, often culminating in premature ovarian insufficiency. These therapies, particularly alkylating agents and ionizing radiation, induce DNA damage and apoptosis in ovarian follicles, leading to infertility, amenorrhea, and estrogen deficiency, which exacerbate risks of osteoporosis and cardiovascular diseases. Existing fertility preservation methods do not prevent immediate ovarian damage, underscoring the need for innovative protective strategies. Menstrual blood-derived stem cells (MenSC) and their extracellular vesicles (EV) present promising regenerative potential due to their therapeutic cargo delivery and pathway modulation capabilities. Preclinical studies demonstrate that MenSC-derived EV ameliorate premature ovarian insufficiency by inhibiting granulosa cell apoptosis, promoting angiogenesis, and activating pivotal pathways such as SMAD3/AKT/MDM2/P53. However, comprehensive research is imperative to ensure the safety, efficacy, and long-term effects of MenSC-derived EV in clinical practice. In this review, we update the current knowledge and research regarding the use of MenSC-derived EV as a novel therapeutic weapon for ovarian regeneration in the context of gonadotoxicity induced by systemic anticancer treatment.

引用

页数：14

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