Therapeutic Transplantation of Human Central Nervous System Organoids for Neural Reconstruction

被引:0
作者
Hong, Sung Jun [1 ,2 ]
Bock, Minsung [3 ]
Zhang, Songzi [3 ]
An, Seong Bae [3 ]
Han, Inbo [3 ]
机构
[1] CHA Univ, Sch Med, Res Competency Milestones Program RECOMP, Seongnam Si 13488, South Korea
[2] CHA Univ, Sch Med, Dept Med, Seongnam Si 13496, South Korea
[3] CHA Univ, CHA Bundang Med Ctr, Dept Neurosurg, Seongnam Si 13496, South Korea
基金
新加坡国家研究基金会;
关键词
central nervous system; organoid; neural reconstruction; transplantation; TRAUMATIC BRAIN-INJURY; CEREBRAL ORGANOIDS; STEM-CELLS; MIDBRAIN ORGANOIDS; MODELS; INTEGRATION; CHALLENGES; DIVERSITY; STROKE; REPAIR;
D O I
10.3390/ijms25158540
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Damage to the central nervous system (CNS) often leads to irreversible neurological deficits, and there are currently few effective treatments available. However, recent advancements in regenerative medicine have identified CNS organoids as promising therapeutic options for addressing CNS injuries. These organoids, composed of various neurons and supporting cells, have shown potential for direct repair at injury sites. CNS organoids resemble the structure and function of actual brain tissue, which allows them to adapt and function well within the physiological environment when transplanted into injury sites. Research findings suggest that CNS organoids can replace damaged neurons, form new neural connections, and promote neural recovery. This review highlights the emerging benefits, evaluates preclinical transplantation outcomes, and explores future strategies for optimizing neuroregeneration using CNS organoids. With continued research and technological advancements, these organoids could provide new hope for patients suffering from neurological deficits.
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收藏
页数:14
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