Targeting epigenetic enzymes for autism treatment

被引：0
|
作者：
Yan, Zhen [1 ]
机构：
[1] SUNY Buffalo, Jacobs Sch Med & Biomed Sci, Dept Physiol & Biophys, Buffalo, NY 14203 USA
来源：
TRENDS IN PHARMACOLOGICAL SCIENCES | 2024年 / 45卷 / 09期
基金：
美国国家卫生研究院;
关键词：
MOUSE MODEL;
D O I：
10.1016/j.tips.2024.06.009
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Emerging preclinical autism research has shown the therapeutic promise of pharmacological inhibitors for epigenetic enzymes, such as histone deacetylases (HDAC), euchromatic histone methyltransferases (EHMT), and lysine-specific histone demethylase 1A (LSD1). These interventions restore gene expression, synaptic function, and behavioral performance in autism models, highlighting a new strategy for autism treatment.
引用
收藏
页码：764 / 767
页数：4
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