EFFECTS OF VACCINATION AND SATURATED TREATMENT ON COVID-19 TRANSMISSION IN INDIA: DETERMINISTIC AND STOCHASTIC APPROACHES

被引:4
作者
Saha, Pritam [1 ]
Pal, Kalyan Kumar [2 ]
Ghosh, Uttam [1 ]
Tiwari, Pankaj Kumar [2 ]
机构
[1] Univ Calcutta, Dept Appl Math, Kolkata 700009, India
[2] Indian Inst Informat Technol, Dept Basic Sci & Humanities, Bhagalpur 813210, India
关键词
COVID-19; Parameter estimation; Backward bifurcation; Sensitivity analysis; Stationary distribution; SENSITIVITY-ANALYSIS; MODEL; UNCERTAINTY; DYNAMICS; OUTBREAK;
D O I
10.1142/S021833902450044X
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
This study explores an epidemic model elucidating the dynamics of COVID-19 transmission amidst vaccination and saturated treatment interventions. The investigation encompasses both deterministic and stochastic frameworks, considering constant and fluctuating environments, utilizing COVID-19 data from India for empirical validation. Through rigorous mathematical and numerical analyses, we ascertain pivotal insights. Our deterministic model unveils a critical phenomenon: the occurrence of backward bifurcation at R-0 = 1, underscoring that merely reducing the basic reproduction number below unity does not ensure disease eradication. Sensitivity analyses underscore the acceleration of epidemic spread with higher transmission rates, yet mitigation measures such as vaccination and comprehensive treatment can effectively reduce the basic reproduction number below unity. Within the stochastic framework, we establish the existence of a unique global positive solution. We delineate conditions for disease extinction or persistence and identify criteria for the emergence of stationary distribution, reflecting the sustained presence of infection within the community. Our findings elucidate that while smaller noise intensities sustain disease prevalence, heightened noise levels lead to complete eradication of the infection.
引用
收藏
页码:53 / 99
页数:47
相关论文
共 55 条
[1]  
Alagoz O, 2021, PLOS ONE, V16, DOI [10.1371/journal.pone.0254456, 10.1101/2021.03.22.21254131]
[2]  
[Anonymous], 2019, U.S
[3]   Mathematical analysis of a stochastic model for spread of Coronavirus [J].
Babaei, A. ;
Jafari, H. ;
Banihashemi, S. ;
Ahmadi, M. .
CHAOS SOLITONS & FRACTALS, 2021, 145
[4]   SENSITIVITY AND UNCERTAINTY ANALYSIS OF COMPLEX-MODELS OF DISEASE TRANSMISSION - AN HIV MODEL, AS AN EXAMPLE [J].
BLOWER, SM ;
DOWLATABADI, H .
INTERNATIONAL STATISTICAL REVIEW, 1994, 62 (02) :229-243
[5]   Dynamical models of tuberculosis and their applications [J].
Castillo-Chavez, C ;
Song, BJ .
MATHEMATICAL BIOSCIENCES AND ENGINEERING, 2004, 1 (02) :361-404
[6]   The asymptotic behavior of a stochastic vaccination model with backward bifurcation [J].
Chen, Can ;
Kang, Yanmei .
APPLIED MATHEMATICAL MODELLING, 2016, 40 (11-12) :6051-6068
[7]   Determining important parameters in the spread of malaria through the sensitivity analysis of a mathematical model [J].
Chitnis, Nakul ;
Hyman, James M. ;
Cushing, Jim M. .
BULLETIN OF MATHEMATICAL BIOLOGY, 2008, 70 (05) :1272-1296
[8]   The construction of next-generation matrices for compartmental epidemic models [J].
Diekmann, O. ;
Heesterbeek, J. A. P. ;
Roberts, M. G. .
JOURNAL OF THE ROYAL SOCIETY INTERFACE, 2010, 7 (47) :873-885
[9]   Stationary distribution and extinction of stochastic coronavirus (COVID-19) epidemic model [J].
Din, Anwarud ;
Khan, Amir ;
Baleanu, Dumitru .
CHAOS SOLITONS & FRACTALS, 2020, 139
[10]   Modeling the second wave of COVID-19 infections in France and Italy via a stochastic SEIR model [J].
Faranda, Davide ;
Alberti, Tommaso .
CHAOS, 2020, 30 (11)