Relationship between ferroptosis and mitophagy in acute lung injury: a mini-review

被引：0
作者：
Cheng, Yunhua [1 ,2 ]
Zhu, Liling [3 ]
Xie, Shuangxiong [1 ,2 ]
Lu, Binyuan [1 ,2 ]
Du, Xiaoyu [4 ]
Ding, Guanjiang [1 ,2 ]
Wang, Yan [1 ,2 ]
Ma, Linchong [2 ]
Li, Qingxin [2 ]
机构：
[1] Gansu Univ Chinese Med, Sch Clin Med 1, Lanzhou, Gansu, Peoples R China
[2] 940th Hosp Joint Logist Support Force Chinese Peop, Dept Thorac Surg, Lanzhou, Gansu, Peoples R China
[3] Hunan Childrens Hosp, Dept Anesthesiol, Changsha, Hunan, Peoples R China
[4] Northwest Minzu Univ, Med Coll, Lanzhou, Gansu, Peoples R China
来源：
PEERJ | 2024年 / 12卷
关键词：
Acute lung injury; Ferroptosis; Mitochondria; Mitophagy; Relationship; Mechanism; QUALITY-CONTROL; INFLAMMATION; INHIBITION; MECHANISMS; AUTOPHAGY; PATHWAY; STRESS; FUNDC1;
D O I：
10.7717/peerj.18062
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Acute lung injury (ALI) is one of the most deadly and prevalent diseases in the intensive care unit. Ferroptosis and mitophagy are pathological mechanisms of ALI. Ferroptosis aggravates ALI, whereas mitophagy regulates ALI. Ferroptosis and mitophagy are both closely related to reactive oxygen species (ROS). Mitophagy can regulate ferroptosis, but the specific relationship between ferroptosis and mitophagy is still unclear. This study summarizes previous research findings on ferroptosis and mitophagy, revealing their involvement in ALI. Examining the functions of mTOR and NLPR3 helps clarify the connection between ferroptosis and mitophagy in ALI, with the goal of establishing a theoretical foundation for potential therapeutic approaches in the future management of ALI.
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页数：25
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