Pharmacogenetics of angiotensin-converting enzyme inhibitors (ACEI) and angiotensin II receptor blockers (ARB) in cardiovascular diseases

被引：5

作者：

Agostini, Livia da Cunha ^{[1
]}

Silva, Nayara Nascimento Toledo ^{[2
]}

Belo, Vanessa de Almeida ^{[3
]}

Luizon, Marcelo Rizzatti ^{[4
]}

Lima, Angelica Alves ^{[2
]}

da Silva, Glenda Nicioli ^{[2
]}

机构：

[1] Univ Federalde Ouro Preto, Programa Posgrad Ciencias Farmaceut CiPharma, Escola Farm, BR-35400000 Ouro Preto, MG, Brazil

[2] Univ Federalde Ouro Preto, Dept Anal Clin DEACL, Escola Farm, BR-35400000 Ouro Preto, MG, Brazil

[3] Univ Fed Ouro Preto, Dept Farm DEFAR, Escola Farm, BR-35400000 Ouro Preto, MG, Brazil

[4] Univ Fed Minas Gerais, Dept Genet Ecol & Evolucao, Inst Ciencias Biol, BR-31270901 Belo Horizonte, MG, Brazil

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 2024年 / 981卷

关键词：

Angiotensin-converting enzyme inhibitors; Angiotensin II receptor blockers; Cardiovascular diseases; Hypertension; Pharmacogenetics; Single nucleotide polymorphisms; BLOOD-PRESSURE RESPONSE; GENE INSERTION/DELETION POLYMORPHISM; LEFT-VENTRICULAR HYPERTROPHY; GENOME-WIDE ASSOCIATION; INDUCED COUGH; ANTIHYPERTENSIVE RESPONSES; MYOCARDIAL-INFARCTION; AFRICAN-AMERICANS; HYPERTENSION; ENALAPRIL;

D O I：

10.1016/j.ejphar.2024.176907

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Cardiovascular diseases (CVDs) have a high mortality rate, and despite the several available therapeutic targets, non-response to antihypertensives remains a common problem. Angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) are important classes of drugs recommended as first-line therapy for several CVDs. However, response to ACEIs and ARBs varies among treated patients. Pharmacogenomics assesses how an individual's genetic characteristics affect their likely response to drug therapy. Currently, numerous studies suggest that genetic polymorphisms may contribute to variability in drug response. Moreover, further studies evaluating gene-gene interactions within signaling pathways in response to antihypertensives might help to unravel potential genetic predictors for antihypertensive response. This review summarizes the pharmacogenetic data for ACEIs and ARBs in patients with CVD, and discusses the potential pharmacogenetics of these classes of antihypertensives in clinical practice. However, replication studies in different populations are needed. In addition, studies that evaluate gene-gene interactions that share signaling pathways in the response to antihypertensive drugs might facilitate the discovery of genetic predictors for antihypertensive response.

引用

页数：11

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