Novel ionic polymers encompassing di-cationic pyridinium hydrazones and aromatic ester as potent antimicrobial agents against resistant bacteria

In this work, readily achievable synthetic pathways including quaternization, metathesis and copolymerization reactions were utilized for the construction of a new di-pyridinium monomers and their respected ionic polymers scaffold with ester fragments. All synthesized material were well characterized by spectroscopic experiments. The surface morphology and thermal study of the produced polyesters were carried out using SEM, PXRD, and TGA analysis. The impact of the counter anions on the crystallinity and thermal analysis of the polymer network was confirmed by thermal analysis and surface investigation. The related polyesters' crystallinity was decreased, and their thermal stability was increased by the TFSI anion. Various significant consequences regarding the development of innovative antibacterial agents along with specific therapies. Subsequently, we evaluated the antimicrobial, antibiotic resistant strains, and anti-prophage properties of these novel class of ionic and polyionic materials. Throughout antibacterial studies, the M-Br monomer excelled all synthesized materials, although PPy-TFSI and its monomer outperformed antibiotic-resistant organisms. Both M-PF6 and PPy-PF6 decreased S. aureus bacteriophage proliferation. Understanding the bacterial species or strains that are vulnerable to polyesters encourages subsequent studies in this field to focus on creating targeted therapies for illnesses caused by these pathogens.