Benzothiazole a privileged scaffold for Cutting-Edges anticancer agents: Exploring drug design, structure-activity relationship, and docking studies

被引：8

作者：

Aayishamma, I ^{[1
]}

Matada, Gurubasavaraja Swamy Purawarga ^{[1
]}

Pal, Rohit ^{[1
]}

Ghara, Abhishek ^{[1
]}

Aishwarya, Nimmagadda Venkata Satya Sai ^{[1
]}

Kumaraswamy, B. ^{[1
]}

Hosamani, Ketan R. ^{[1
]}

V. Manjushree, B. ^{[1
]}

Haripriya, E. ^{[1
]}

机构：

[1] Acharya & BM Reddy Coll Pharm, Integrated Drug Discovery Ctr, Dept Pharmaceut Chem, Bengaluru 560107, Karnataka, India

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2024年 / 279卷

关键词：

Benzothiazole; Anticancer; Cytotoxicity; SAR; Docking; Designing strategies; BIOLOGICAL EVALUATION; CANCER; DERIVATIVES; PROJECTION; CHEMISTRY; LIBRARIES;

D O I：

10.1016/j.ejmech.2024.116831

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Cancer is a major societal, public health, and economic burden in the 21st century, with 9.7 million deaths in 2022 (9.96 million in 2020) and 20 million new cancer cases (19.6 million in 2020). Considering the increasing number of cancer cases and deaths, heterocyclic compounds always paved the gold mine for the development of potential anticancer drugs as these compounds have unique flexibility and dynamic cores. Benzothiazoles and their derivatives have potential anticancer properties, making them a desirable scaffold among different heterocycles. Title structures are a class of chemicals that may bind to various receptors with high affinity, particularly those engaged in oncogenic processes. The use of these compounds allows medicinal chemists to rapidly produce anticancer treatments across a large range of targets over an extended length of time. The current study presents a thorough success story of benzothiazole derivatives as anticancer agents. It discusses the current state of cancer, the profile of benzothiazole-based derivatives synthetic pathways, and its relevance as an anticancer agent on several oncogenic pathways. The structure-activity relationship was also added to offer insight into the connection of biological data with structure and the rational design of more active drugs.

引用

页数：23

共 96 条

[21] Discovery of novel pyrimidine-based benzothiazole derivatives as potent cyclin-dependent kinase 2 inhibitors with anticancer activity [J].