Impact of breastfeeding on risk of glucose intolerance in early postpartum after gestational diabetes

被引：1

作者：

Vanlaer, Yana ^{[1
]}

Minschart, Caro ^{[1
]}

Vrolijk, Hannah ^{[2
]}

Van Crombrugge, Paul ^{[3
]}

Moyson, Carolien ^{[1
]}

Verhaeghe, Johan ^{[4
]}

Devlieger, Roland ^{[4
,5
,6
]}

Vandeginste, Sofie ^{[7
]}

Verlaenen, Hilde ^{[7
]}

Vercammen, Chris ^{[8
]}

Maes, Toon ^{[8
]}

Dufraimont, Els ^{[9
]}

Roggen, Nele ^{[9
]}

De Block, Christophe ^{[10
]}

Jacquemyn, Yves ^{[11
,12
,13
]}

Mekahli, Farah ^{[14
]}

De Clippel, Katrien ^{[15
]}

Van Den Bruel, Annick ^{[16
]}

Loccufier, Anne ^{[17
]}

Van Pottelbergh, Inge ^{[18
]}

Myngheer, Nele ^{[19
]}

Abrams, Pascale ^{[20
,21
]}

Vinck, Wouter ^{[21
]}

Leuridan, Liesbeth ^{[22
]}

Driessens, Sabien ^{[22
]}

Billen, Jaak ^{[23
]}

Matthys, Christophe ^{[24
]}

Bogaerts, Annick ^{[25
,26
]}

Laenen, Annouschka ^{[27
]}

Mathieu, Chantal ^{[1
]}

Benhalima, Katrien ^{[1
]}

机构：

[1] Katholieke Univ Leuven, Dept Chron Dis & Metab, Clin & Expt Endocrinol, Leuven, Belgium

[2] Katholieke Univ Leuven, Fac Med, Leuven, Belgium

[3] OLV Ziekenhuis Aalst Asse Ninove, Dept Endocrinol, Aalst, Belgium

[4] Katholieke Univ Leuven, UZ Gasthuisberg, Dept Obstetr & Gynecol, Leuven, Belgium

[5] Katholieke Univ Leuven, Dept Dev & Regenerat, Res Unit Woman & Child, REALIFE Res Grp, Leuven, Belgium

[6] GZA Hosp Sint Augustinus, Dept Obstet & Gynecol, Antwerp, Belgium

[7] OLV Ziekenhuis Aalst Asse Ninove, Dept Obstet & Gynecol, Aalst, Belgium

[8] Imelda Ziekenhuis, Dept Endocrinol, Bonheiden, Belgium

[9] Imelda Ziekenhuis, Dept Obstet & Gynecol, Bonheiden, Belgium

[10] Antwerp Univ Hosp, Dept Endocrinol Diabetol & Metab, Edegem, Belgium

[11] Univ Antwerp Hosp, Dept Obstet & Gynecol, Edegem, Belgium

[12] Univ Antwerp, ASTARC, Antwerp, Belgium

[13] Antwerp Univ, GHI, Antwerp, Belgium

[14] Kliniek St Jan Brussel, Dept Endocrinol, Brussels, Belgium

[15] Klin St Jan Brussel, Dept Obstet & Gynecol, Brussels, Belgium

[16] AZ St Jan Brugge, Dept Endocrinol, Brugge, Belgium

[17] AZ St Jan Brugge, Dept Obstet & Gynecol, Brugge, Belgium

[18] OLV Hosp Aalst, Dept Endocrinol, Aalst, Belgium

[19] Gen Hosp Groeninge, Dept Endocrinol, Kortrijk, Belgium

[20] ZAS Hosp Sint Vincentius, Dept Endocrinol, Antwerp, Belgium

[21] ZAS Hosp Sint Augustinus, Dept Endocrinol, Antwerp, Belgium

[22] Gen Hosp Klina, Dept Endocrinol, Brasschaat, Belgium

[23] Univ Hosp Leuven, Dept Lab Med, Leuven, Belgium

[24] Univ Hosp Leuven, Dept Endocrinol, Leuven, Belgium

[25] Katholieke Univ Leuven, Dept Dev & Regenerat, Leuven, Belgium

[26] Univ Plymouth, Fac Hlth, Plymouth, Devon, England

[27] Katholieke Univ Leuven, Ctr Biostat & Statist Bioinformat, Leuven, Belgium

来源：

FRONTIERS IN ENDOCRINOLOGY | 2024年 / 15卷

关键词：

breastfeeding; mixed milk feeding; postpartum glucose intolerance; gestational diabetes mellitus; impaired beta-cell function; insulin resistance; BLOOD-PRESSURE; WEIGHT RETENTION; WOMEN; LACTATION; PREGNANCY; ASSOCIATION; TOLERANCE; OXYTOCIN; DURATION; MELLITUS;

D O I：

10.3389/fendo.2024.1374682

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Aims To determine the impact of breastfeeding on the risk of postpartum glucose intolerance in women with gestational diabetes.Methods Sub-analysis of two multi-centric prospective cohort studies (BEDIP-N and MELINDA) in 1008 women with gestational diabetes. Data were collected during pregnancy and at a mean of 12 weeks postpartum. Multivariate logistic regression was used to estimate the effect of breastfeeding on glucose intolerance, with adjustment for ethnicity, education, income, professional activity and BMI.Results Of all participants, 56.3% (567) breastfed exclusively, 10.1% (102) gave mixed milk feeding and 33.6% (339) did not breastfeed. Mean breastfeeding duration was 3.8 +/- 2.4 and 3.7 +/- 2.1 months in the breastfeeding and mixed milk feeding groups (p=0.496). The rate of glucose intolerance was lower in both the breastfeeding [22.3% (126)] and mixed milk feeding [25.5% (26)] groups compared to the no breastfeeding group [29.5% (100)], with an adjusted OR of 0.7 (95% CI 0.5-1.0) for glucose intolerance in the breastfeeding group compared to no breastfeeding group and an adjusted OR of 0.7 (95% CI 0.4-1.2) for the mixed milk feeding group compared to the no breastfeeding group. Postpartum, breastfeeding women had a lower BMI, less often postpartum weight retention, lower fasting triglycerides, less insulin resistance and a higher insulin secretion-sensitivity index-2 than the mixed milk feeding and no breastfeeding group. The mixed milk feeding group was more often from an non-White background, had a lower blood pressure and lower fasting triglycerides compared to the no breastfeeding group.Conclusions Breastfeeding (exclusive and mixed milk feeding) is associated with less glucose intolerance and a better metabolic profile in early postpartum in women with gestational diabetes.

引用

页数：10

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