Alteration of Trophoblast Syncytialization by Plasmodium falciparum-Infected Erythrocytes

被引:1
作者
Lopez-Guzman, Carolina [1 ]
Garcia, Ana Maria [1 ]
Vasquez, Ana Maria [1 ,2 ]
机构
[1] Univ Antioquia, Fac Med, Grp Malaria, Calle 62 52-59,Torre 1,Lab 610, Medellin 050001, Colombia
[2] Univ Antioquia, Escuela Microbiol, Calle 67 53-108,Bloque 5,Oficina 5-135, Medellin 050001, Colombia
关键词
trophoblast; cytotrophoblast; syncytiotrophoblast; Plasmodium falciparum; malaria; CHONDROITIN-SULFATE-A; TRYPANOSOMA-CRUZI; HUMAN PLACENTA; PREGNANCY; MALARIA; FUSION; GROWTH; SYNCYTIOTROPHOBLAST; EXPRESSION; APOPTOSIS;
D O I
10.3390/microorganisms12081640
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Malaria during pregnancy has been associated with significant risks to both the mother and the fetus, leading to complications such as anemia, low birth weight, and increased infant mortality. The trophoblast cells, a key component of the placenta, are crucial for nutrient and oxygen exchange between mother and fetus. The differentiation of cytotrophoblasts (CTBs) into syncytiotrophoblasts (STBs) is critical for proper pregnancy development. These cells form the bi-stratified epithelium surrounding the placental villi. While previous studies have described an inflammatory activation of STB cells exposed to Plasmodium falciparum-infected erythrocytes (P. falciparum-IE) or components such as hemozoin (HZ), little is known about the direct effect this parasite may have on the epithelial turnover and function of trophoblast cells. This study aims to contribute to understanding mechanisms leading to placental damage during placental malaria using a BeWo cell line as a differentiation model. It was found that P. falciparum-IE interferes with the fusion of BeWo cells, affecting the differentiation process of trophoblast. A reduction in syncytialization could be associated with the adverse effects of infection in fetal health, altering the remodeling of the trophoblast epithelial barrier and reducing their capacity to exchange substances. However, further studies are necessary to assess alterations in the functionality of this epithelium.
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页数:16
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  • [11] Plasmodium falciparum:: Chondroitin sulfate A is the major receptor for adhesion of parasitized erythrocytes in the placenta
    Fried, Michal
    Domingo, Gonzalo J.
    Gowda, Channe D.
    Mutabingwa, Theonest K.
    Duffy, Patrick E.
    [J]. EXPERIMENTAL PARASITOLOGY, 2006, 113 (01) : 36 - 42
  • [12] Systemic Inflammatory Response to Malaria During Pregnancy Is Associated With Pregnancy Loss and Preterm Delivery
    Fried, Michal
    Kurtis, Jonathan D.
    Swihart, Bruce
    Pond-Tor, Sunthorn
    Barry, Amadou
    Sidibe, Youssoufa
    Gaoussou, Santara
    Traore, Moussa
    Keita, Sekouba
    Mahamar, Almahamoudou
    Attaher, Oumar
    Dembele, Adama B.
    Cisse, Kadidia B.
    Diarra, Bacary S.
    Kanoute, Moussa B.
    Dicko, Alassane
    Duffy, Patrick E.
    [J]. CLINICAL INFECTIOUS DISEASES, 2017, 65 (10) : 1729 - 1735
  • [13] Malaria during Pregnancy
    Fried, Michal
    Duffy, Patrick E.
    [J]. COLD SPRING HARBOR PERSPECTIVES IN MEDICINE, 2017, 7 (06):
  • [14] G M., 2008, J F R REPRODUKTIONSM, V5, P76
  • [15] New insights into the regulation of human cytotrophoblast cell differentiation
    Handwerger, Stuart
    [J]. MOLECULAR AND CELLULAR ENDOCRINOLOGY, 2010, 323 (01) : 94 - 104
  • [16] Huppertz B., 2006, J. Reprod. Med. Endocrinol, V3, P103
  • [17] Trophoblast fusion: Fusogenic proteins, syncytins and ADAMs, and other prerequisites for syncytial fusion
    Huppertz, Berthold
    Bartz, Clemens
    Kokozidou, Maria
    [J]. MICRON, 2006, 37 (06) : 509 - 517
  • [18] Placental trophoblast cell differentiation: Physiological regulation and pathological relevance to preeclampsia
    Ji, Lei
    Brkic, Jelena
    Liu, Ming
    Fu, Guodong
    Peng, Chun
    Wang, Yan-Ling
    [J]. MOLECULAR ASPECTS OF MEDICINE, 2013, 34 (05) : 981 - 1023
  • [19] Human placenta and trophoblast development: key molecular mechanisms and model systems
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    Haider, Sandra
    Saleh, Leila
    Pollheimer, Juergen
    Gamage, Teena K. J. B.
    James, Joanna
    [J]. CELLULAR AND MOLECULAR LIFE SCIENCES, 2019, 76 (18) : 3479 - 3496
  • [20] Trophoblast Differentiation: Mechanisms and Implications for Pregnancy Complications
    Lawless, Lauren
    Qin, Yushu
    Xie, Linglin
    Zhang, Ke
    [J]. NUTRIENTS, 2023, 15 (16)