Relationship between Indel Variants within the JAK2 Gene and Growth Traits in Goats

被引:0
|
作者
Wu, Xian-Feng [1 ]
Xu, Qian [1 ]
Wang, Ao [2 ]
Wang, Ben-Zhi [2 ]
Lan, Xian-Yong [3 ]
Li, Wen-Yang [1 ]
Liu, Yuan [1 ]
机构
[1] Fujian Acad Agr Sci, Inst Anim Husb & Vet, Fujian Prov Key Lab Anim Genet & Breeding, Fuzhou 350013, Peoples R China
[2] Fujian Agr & Forestry Univ, Coll Anim Sci, Fuzhou 350002, Peoples R China
[3] Northwest A&F Univ, Coll Anim Sci & Technol, Shaanxi Key Lab Mol Biol Agr, Yangling 712100, Xianyang, Peoples R China
来源
ANIMALS | 2024年 / 14卷 / 13期
关键词
goat; JAK2; gene; insertion/deletion; growth traits; marker-assisted selection (MAS); EXPRESSION; KINASE; DEFICIENCY; RESISTANCE; INTRONS; PATHWAY; TISSUE; CATTLE; CELLS; MICE;
D O I
10.3390/ani14131994
中图分类号
S8 [畜牧、 动物医学、狩猎、蚕、蜂];
学科分类号
0905 ;
摘要
Janus kinase 2 (JAK2) plays a critical role in myoblast proliferation and fat deposition in animals. Our previous RNA-Seq analyses identified a close association between the JAK2 gene and muscle development. To date, research delving into the relationship between the JAK2 gene and growth traits has been sparse. In this study, we sought to investigate the relationship between novel mutations within the JAK2 gene and goat growth traits. Herein, two novel InDel (Insertion/Deletion) polymorphisms within the JAK2 gene were detected in 548 goats, and only two genotypes were designated as ID (Insertion/Deletion) and DD (Deletion/Deletion). The results indicate that the two InDels, the del19008 locus in intron 2 and del72416 InDel in intron 6, showed significant associations with growth traits (p < 0.05). Compared to Nubian and Jianzhou Daer goats, the del72416 locus displayed a more pronounced effect in the Fuqing breed group. In the Nubian breed (NB) group, both InDels showed a marked influence on body height (BH). There were strong linkages observed for these two InDels between the Fuqing (FQ) and Jianzhou (JZ) populations. The DD-ID diplotype was associated with inferior growth traits in chest width (ChW) and cannon circumference (CaC) in the FQ goats compared to the other diplotypes. In the NB population, the DD-DD diplotype exhibited a marked negative impact on BH and HuWI (hucklebone width index), in contrast to the other diplotypes. In summary, our findings suggest that the two InDel polymorphisms within the JAK2 gene could serve as valuable molecular markers for enhancing goat growth traits in breeding programs.
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页数:12
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