Neutrophil Extracellular Trap Formation in Advanced Heart Failure Patients-Preliminary Report

被引：1

作者：

Urbanowicz, Tomasz ^{[1
]}

Olasinska-Wisniewska, Anna ^{[1
]}

Wojtasinska, Ewelina ^{[2
]}

Filipiak, Krzysztof J. ^{[3
,4
]}

Tomaszewska, Malgorzata ^{[5
]}

Sikora, Jedrzej ^{[1
]}

Krama, Marta ^{[1
]}

Radek, Zofia ^{[1
]}

Grodecki, Kajetan

Krasinska-Plachta, Aleksandra ^{[6
]}

Krasinska, Beata ^{[3
]}

Krasinski, Zbigniew ^{[7
,8
]}

Tykarski, Andrzej ^{[3
]}

Jemielity, Marek ^{[1
]}

Rupa-Matysek, Joanna ^{[2
]}

机构：

[1] Poznan Univ Med Sci, Cardiac Surg & Transplantol Dept, PL-61107 Poznan, Poland

[2] Poznan Univ Med Sci, Dept Hematol & Bone Marrow Transplantat, PL-61107 Poznan, Poland

[3] Poznan Univ Med Sci, Dept Hypertensiol Angiol & Internal Med, PL-61107 Poznan, Poland

[4] Mar Sklodowska Curie Med Acad, Inst Clin Sci, PL-00136 Warsaw, Poland

[5] Poznan Univ Med Sci, Cardiol Dept 1, PL-61107 Poznan, Poland

[6] Warsaw Univ Med Sci, Cardiol Dept 1, PL-02091 Warsaw, Poland

[7] Poznan Univ Med Sci, Dept Ophthalmol, PL-61107 Poznan, Poland

[8] Poznan Univ Med Sci, Dept Vasc Endovasc Surg Angiol & Phlebol, PL-61848 Poznan, Poland

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2024年 / 25卷 / 17期

关键词：

neutrophil extracellular trap (NET); citrullinated histone 3 (CH3); heart failure (HF); left ventricular assist device (LVAD); Heartmate; 3; VENTRICULAR ASSIST DEVICE; IMPLANTATION; INFLAMMATION; ACTIVATION; THERAPY; NETOSIS;

D O I：

10.3390/ijms25179633

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In end-stage heart failure, which is characterized by persistent or progressive ventricular dysfunction despite optimal medical therapy, a left ventricular assist device (LVAD) can be beneficial. Congestive heart failure provokes inflammatory and prothrombotic activation. The aim of this study was to evaluate the serum concentration of citrullinated histone 3 (CH3) representing neutrophil extracellular trap (NET) formation in patients referred for LVAD implantation. There were 10 patients with a median age of 61 (57-65) years enrolled in a prospective single-center analysis who underwent LVAD implantation. The CH3 plasma concentration was measured preoperatively and on the 1st and 7th postoperative days, followed by control measurements on the median (Q1-3) 88th (49-143) day. The preoperative CH3 concentration strongly correlated with brain natriuretic peptide (r = 0.879, p < 0.001). Significant differences in CH3 serum concentration were observed between pre- and postoperative measurements, including an increase on the first postoperative day (p < 0.001), as well as a decrease on the seventh day (p = 0.016) and in follow-up (p < 0.001). CH3 concentration, as a marker of NET formation, decreases after LVAD implantation.

引用

页数：11