Predictive Factors for Altered Quality of Life in Patients with Type 2 Diabetes Mellitus

被引:2
作者
Albai, Oana [1 ,2 ,3 ]
Braha, Adina [1 ,2 ]
Timar, Bogdan [1 ,2 ,3 ]
Timar, Romulus [1 ,2 ,3 ]
机构
[1] Victor Babes Univ Med & Pharm, Dept Internal Med Diabet Nutr Metab Dis & Syst Rhe, Timisoara 300041, Romania
[2] Pius Brinzeu Emergency Clin Cty Univ Hosp, Dept Diabet Nutr & Metab Dis Clin, Timisoara 300723, Romania
[3] Victor Babes Univ Med & Pharm, Ctr Mol Res Nephrol & Vasc Dis MOL NEPHRO VASC, Timisoara 300041, Romania
关键词
quality of life; type 2 diabetes mellitus; complications; glycemic control; CARDIOVASCULAR-DISEASES; HRQOL; RISK; CARE;
D O I
10.3390/jcm13154389
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Objectives: To evaluate the quality of life (QoL) in a group of patients with type 2 diabetes (T2DM) and to identify predictive factors to apply the necessary measures to improve it. Methods: For this, 299 patients with T2DM were enrolled in a cross-sectional study, and their QoL was assessed using the EQ-5D-3L questionnaire. All patients underwent clinical exams, routine laboratory tests, and nerve conduction velocity (NCV) at the common peroneal nerve. Results: Patients had a median age of 66 (57; 70) years, median duration of T2DM of 10 (6; 15) years, median HbA1c of 8 (7; 9.3)%, and mean EQ-5D-3L score of 55%. In addition, 9.7% presented extreme difficulty in mobility, 18.5% severe difficulty in self-care, and 16.4% in usual activities. One-third presented with severe pain or discomfort, anxiety, or depression (level 3 EQ-5D-3L). DPN, heart failure (HF), cerebral stroke, and insulin therapy increased the likelihood of a reduced QoL (EQ-5D-3L < 50). The EQ-5D-3L score inversely correlated with serum creatinine, glycemic control, lipid profile, diabetes duration, age, mobility, self-care, pain/discomfort, usual activities, and anxiety/depression and positively correlated with NCV, HDLc, and eGFR. Conclusions: Preventing neuropathic complications, chronic kidney disease, stroke, and HF and obtaining the glycemic and lipid targets could improve the QoL in patients with T2DM.
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页数:13
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