Bioactive polymers: A comprehensive review on bone grafting biomaterials

被引：8

作者：

Pourhajrezaei, Sana ^{[1
]}

Abbas, Zahid ^{[2
]}

Khalili, Mohammad Amin ^{[3
]}

Madineh, Hossein ^{[4
]}

Jooya, Hossein ^{[5
]}

Babaeizad, Ali ^{[6
]}

Gross, Jeffrey D. ^{[7
]}

Samadi, Ali ^{[8
]}

机构：

[1] Amirkabir Univ Technol, Dept Biomed Engn, Tehran, Iran

[2] Univ Bologna, Dept Chem, Bologna, Italy

[3] Univ Tarbiat Modares, Dept Biomat, Tehran, Iran

[4] Univ Tarbiat Modares, Dept Polymer Engn, Tehran, Iran

[5] Ferdowsi Univ Mashhad, Fac Sci, Dept Chem, Biochem Grp, Mashhad, Iran

[6] Semnan Univ Med Sci, Fac Med, Semnan, Iran

[7] ReCELLebrate Regenerat Med Clin, Henderson, NV USA

[8] Bam Univ Med Sci, Sch Med, Dept Basic Sci, Bam, Iran

来源：

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES | 2024年 / 278卷

关键词：

Bone tissue engineering; Biomedical applications; Polymeric biomaterials; GROWTH-FACTOR DELIVERY; DRUG-DELIVERY; COMPOSITE SCAFFOLDS; HYALURONIC-ACID; OSTEOGENIC DIFFERENTIATION; EPSILON-CAPROLACTONE; NANOFIBROUS SCAFFOLD; SILK FIBROIN; STEM-CELLS; FABRICATION;

D O I：

10.1016/j.ijbiomac.2024.134615

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The application of bone grafting materials in bone tissue engineering is paramount for treating severe bone defects. In this comprehensive review, we explore the significance and novelty of utilizing bioactive polymers as grafts for successful bone repair. Unlike metals and ceramics, polymers offer inherent biodegradability and biocompatibility, mimicking the native extracellular matrix of bone. While these polymeric micro-nano materials may face challenges such as mechanical strength, various fabrication techniques are available to overcome these shortcomings. Our study not only investigates diverse biopolymeric materials but also illuminates innovative fabrication methods, highlighting their importance in advancing bone tissue engineering.

引用

页数：28

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