Synthesis, Therapeutic Potential, Quantum Studies and Molecular Properties of Amino Acid Fused 1,3,4-Oxadiazole Derivatives as an Unnatural Amino Acids

Background: In present study 1,3,4-oxadiazole derivatives with iso-sterically fused amino acids was attempted to synthesize. As variety of chemical reactions that 1, 3 and 4-oxadiazole molecules can experience, it made them very useful for searching of molecule altogether its high advantaged structure having enormous biological potential. Heterocyclic ring fusion has yielded compounds with a diverse array of biological functions. In the biological system, amino acids are important. With the hope that adding amino acids to an oxadiazole scaffold may result in new molecules that are potentially referred to as unnatural amino acids, this experiment helps to synthesize substances. It is possible to create novel hormones, enzymes and medications using unconventional amino acids. Materials and Methods: Derivatives were tried to synthesize from two methods, conventional as well as new microwave method in order to find out highest yielding method. Microwave method also referred to as "green chemistry" because it uses no external energy sources to produce any harmful fumes, gases, or heat. The synthesised compounds were analysed for their therapeutic potential, molecular properties and quantum studies. Results: "Method B" i.e., microwave used method found to be produce high yield. Synthesised derivatives of fused amino acids with 1,3,4-oxadiazole were said to be unnatural amino acids. The compound(s) were analysed using UV, IR, Mass and NMR spectral data. Synthesized compound(s) were experienced for in vitro DPPH activity with quantum studies, antibacterial potential and anti-fungal activity and found that compound 1A and 1B to have promising activity. Conclusion: The synthesis of fused amino acids is a field of recent study that is gaining interest. Study provides preparation of fused oxadiazole as an Unnatural amino acid and for its similar compound(s). The findings might make a significant contribution to the future development of innovative medicinal medications.