Regulatory effect of N6-methyladenosine on tumor angiogenesis

被引:2
作者
YuYan, Enwu [1 ]
Yuan, Enwu [1 ]
机构
[1] Zhengzhou Univ, Affiliated Hosp 3, Dept Lab Med, Zhengzhou, Henan, Peoples R China
来源
FRONTIERS IN IMMUNOLOGY | 2024年 / 15卷
关键词
N6-methyladenosine; tumor; noncoding RNA; angiogenesis; regulatory role; anti-tumor therapy; DEMETHYLASE FTO INHIBITORS; GASTRIC-CANCER PROGRESSION; MESSENGER-RNA METHYLATION; ENDOTHELIAL GROWTH-FACTOR; NONCODING RNA; NUCLEAR-RNA; HEPATOCELLULAR-CARCINOMA; MEDIATED REGULATION; M(6)A METHYLATION; M6A MODIFICATION;
D O I
10.3389/fimmu.2024.1453774
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Previous studies have demonstrated that genetic alterations governing epigenetic processes frequently drive tumor development and that modifications in RNA may contribute to these alterations. In the 1970s, researchers discovered that N6-methyladenosine (m6A) is the most prevalent form of RNA modification in advanced eukaryotic messenger RNA (mRNA) and noncoding RNA (ncRNA). This modification is involved in nearly all stages of the RNA life cycle. M6A modification is regulated by enzymes known as m6A methyltransferases (writers) and demethylases (erasers). Numerous studies have indicated that m6A modification can impact cancer progression by regulating cancer-related biological functions. Tumor angiogenesis, an important and unregulated process, plays a pivotal role in tumor initiation, growth, and metastasis. The interaction between m6A and ncRNAs is widely recognized as a significant factor in proliferation and angiogenesis. Therefore, this article provides a comprehensive review of the regulatory mechanisms underlying m6A RNA modifications and ncRNAs in tumor angiogenesis, as well as the latest advancements in molecular targeted therapy. The aim of this study is to offer novel insights for clinical tumor therapy.
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页数:21
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