共 53 条
MDMA-assisted brief cognitive behavioral conjoint therapy for PTSD: Study protocol for a pilot study
被引:1
作者:
Morland, L. A.
[1
,2
,3
]
Perivoliotis, D.
[2
,3
]
Wachsman, T. R.
[2
]
Alam, A.
[2
,3
]
Knopp, K.
[2
,3
]
Khalifian, C.
[2
,3
]
Ramanathan, D.
[2
,3
]
Chargin, B. E.
[2
]
Bismark, A. W.
[2
,3
]
Glynn, S.
[4
,5
]
Stauffer, C.
[6
,7
]
Wagner, A. C.
[8
,9
]
机构:
[1] Natl Ctr PTSD, Dept Vet Affairs, Womens Hlth Sci Div, 150 South Huntington St, Boston, MA 02130 USA
[2] Vet Affairs San Diego Healthcare Syst, 3350 La Jolla Village Dr, San Diego, CA 92161 USA
[3] Univ Calif San Diego, Dept Psychiat, 9500 Gilman Dr, La Jolla, CA 92093 USA
[4] VA Greater Los Angeles Healthcare Syst, 11301 Wilshire Blvd, Los Angeles, CA 90073 USA
[5] Univ Calif Los Angeles, Semel Inst Neurosci & Human Behav, 760 Westwood Plaza, Los Angeles, CA 90024 USA
[6] Oregon Hlth & Sci Univ, Dept Psychiat, 3181 SW Sam Jackson Pk Rd, Portland, OR 97239 USA
[7] Vet Affairs Portland Hlth Care Syst, 3710 SW US Vet Hosp Rd, Portland, OR 97239 USA
[8] Remedy, 703 Bloor St West,Suite 201, Toronto, ON M6G 1L5, Canada
[9] Toronto Metropolitan Univ, Dept Psychol, 350 Victoria St, Toronto, ON M5B 2K3, Canada
关键词:
PTSD;
MDMA;
Intimate relationships;
Brief cognitive-behavioral conjoint therapy;
POSTTRAUMATIC-STRESS-DISORDER;
MENTAL-HEALTH-SERVICES;
DEPLOYMENT;
INTERVIEW;
VALIDITY;
RISK;
TOOL;
D O I:
10.1016/j.conctc.2024.101314
中图分类号:
R-3 [医学研究方法];
R3 [基础医学];
学科分类号:
1001 ;
摘要:
Background: Posttraumatic Stress Disorder (PTSD) impacts both individual and relational functioning. Veteran couples are at increased risk of relationship distress due to military stressors such as deployment, family reintegration, and traumatic stress. Although both Cognitive-Behavioral Conjoint Therapy (CBCT) and its brief version (bCBCT) consistently have large effects on reducing PTSD symptoms, these treatments have more variable effects on relational outcomes. Given the impact of relationship functioning on the overall health of veterans, improving the effect of PTSD treatments on relationship functioning is an essential area of research. One promising path is the role of MDMA (3,4-methylenedioxymethamphetamine)-assisted therapy in augmenting the relational impact of established therapeutic interventions such as bCBCT. Method/Design: This is a single site, open-label study assessing the preliminary efficacy, safety, and acceptability of MDMA-assisted therapy in combination with bCBCT in 8 veterans with PTSD and their intimate partners (N = 16). Therapy teams trained in bCBCT and MDMA-assisted therapy will deliver bCBCT combined with two MDMA sessions and two couple emotion focused integration sessions. PTSD symptom severity and relationship functioning outcomes will be evaluated. Conclusion: This is the first study to examine the efficacy of MDMA-assisted bCBCT for improving PTSD and relationship functioning among a sample of U.S. military veterans and their partners. This project could provide an opportunity to pilot a scalable model of treating PTSD within the Veterans Affairs healthcare system and leverage the benefits of MDMA for veterans with PTSD, as well as the downstream benefits to their partner on both individual and relationship functioning. ClinicalTrials.gov Identifier: NCT05979844.
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