Dedifferentiating myoblasts back into a satellite cell state in vitro

被引：0
|
作者：
Price, Feodor [1 ]
Rubin, Lee [1 ]
机构：
[1] Harvard Univ, Cambridge, MA 02138 USA
来源：
NATURE BIOTECHNOLOGY | 2024年
关键词：
D O I：
10.1038/s41587-024-02345-6
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Satellite cells, the stem cells of skeletal muscle, are responsible for muscle development and regeneration. Although low in abundance, satellite cells can be isolated from muscle but cannot be propagated successfully in culture in numbers needed for therapeutic use. We developed a method to generate cells with satellite cell characteristics from skeletal muscle organoid cultures.
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页数：2
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