General control nonderepressible 2 (GCN2) as a therapeutic target in age-related diseases

被引：0
|
作者：
Altintas, Ozlem [1 ]
MacArthur, Michael R. [1 ,2 ]
机构：
[1] Swiss Fed Inst Technol, Dept Hlth Sci & Technol, Zurich, Switzerland
[2] Princeton Univ, Lewis Sigler Inst Integrat Genom, Princeton, NJ 08544 USA
来源：
FRONTIERS IN AGING | 2024年 / 5卷
关键词：
GCN2; ISR; amino acids; aging; gerotherapeutic; geroprotection; cancer; AMINO-ACID DEPRIVATION; PROTEIN-KINASE GCN2; SENSOR GCN2; TRANSLATIONAL CONTROL; TRANSFER-RNA; T-CELLS; ACTIVATION; STRESS; BINDING; PHOSPHORYLATION;
D O I：
10.3389/fragi.2024.1447370
中图分类号：
R592 [老年病学]; C [社会科学总论];
学科分类号：
03 ; 0303 ; 100203 ;
摘要：
The function of General Control Nonderepressible 2 (GCN2), an evolutionary-conserved component of the integrated stress response (ISR), has been well-documented across organisms from yeast to mammals. Recently GCN2 has also gained attention for its role in health and disease states. In this review, we provide a brief overview of GCN2, including its structure, activation mechanisms and interacting partners, and explore its potential significance as a therapeutic target in various age-related diseases including neurodegeneration, inflammatory disorders and cancer. Finally, we summarize the barriers to effectively targeting GCN2 for the treatment of disease and to promote a healthier aging process.
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页数：8
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