IBD functions as a double-edged sword for food allergy in BALB/c mice model

被引:0
作者
Chen, Bihua [1 ,2 ,3 ]
Wu, Yuhong [1 ,2 ,3 ]
Wu, Huan [1 ,2 ,3 ]
Gao, Jinyan [1 ,2 ,3 ]
Meng, Xuanyi [1 ,3 ,4 ]
Chen, Hongbing [1 ,3 ,4 ]
机构
[1] Nanchang Univ, State Key Lab Food Sci & Resources, Nanchang 330047, Peoples R China
[2] Nanchang Univ, Coll Food Sci & Technol, Nanchang, Peoples R China
[3] Nanchang Univ, Jiangxi Prov Key Lab Food Allergy, Nanchang, Peoples R China
[4] Nanchang Univ, Jiangxi OAI Joint Res Inst, Nanchang, Peoples R China
基金
中国国家自然科学基金;
关键词
food allergy; gut microbiota; inflammatory bowel disease; mucosal immune system; Th2; cytokine; THYMIC STROMAL LYMPHOPOIETIN; FECAL MICROBIOTA; MAST-CELLS; SENSITIZATION; CHILDREN; IL-33; ANAPHYLAXIS; DIVERSITY; DISEASE; MUCOSA;
D O I
10.1111/imm.13833
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Inflammatory bowel disease (IBD) and food allergy (FA) increase in tandem, but the potential impact of IBD on FA remains unclear. We sought to determine the role of IBD on FA. We first assessed the changes of FA-related risk factors in dextran sulphate sodium salt (DSS) induced colitis mice model. Then, we evaluated the role of IBD on FA in mice. FA responses were determined using a clinical allergy score, body temperature change, serum antibody levels, cytokines level and mouse mast cell protease 1 (MMCP-1) concentration. Accumulation of regulatory T cells was tested using flow cytometry. Intestinal changes were identified by histology, immunohistochemistry, gene expression and gut microbial community structure. In DSS-induced colitis mice model, we found the intestinal damage, colonic neutrophil infiltration, and downregulation of splenic Th2 cytokines and Tregs in mesenteric lymph nodes (MLN). Moreover, we also found that IBD can alleviate the FA symptoms and lead to the significant downregulation of Th2 cytokines, serum IgE and MMCP-1. However, IBD exacerbates intestinal injury and promotes the gene expression levels of IL-33 and IL-5 in the small intestine, damages the intestinal tissue structure and aggravates intestinal dysbiosis in FA. IBD functions as a double-edged sword in FA. From the perspective of clinical symptoms and humoral immune responses, IBD can reduce FA response by downregulating Th2 cytokines. But from the perspective of the intestinal immune system, IBD potentially disrupts intestinal tolerance to food antigens by damaging intestinal tissue structure and causing intestinal dysbiosis.
引用
收藏
页码:394 / 407
页数:14
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