Acute and sub-acute Toxicity Profiles of Anchusa strigosa and Zataria Multiflora: Insights from wistar albino rats

被引：0

作者：

Sheikh, Wajid Mohammad ^{[1
,2
]}

Jadhav, Indrani ^{[2
]}

Shafi, Majid ^{[5
]}

Bashir, Showkeen Muzamil ^{[1
]}

Jan, Jasmeena ^{[1
,3
]}

Kalam, Mohd Afsahul ^{[4
]}

Shah, Showkat Ahmad ^{[5
]}

Shah, Abdul Jalil ^{[6
]}

Yousuf, Shahid ^{[1
]}

机构：

[1] Sher Ekashmir Univ Agr Sci & Technol, Fac Vet Sci & Anim Husb, Div Vet Biochem, Biochem & Mol Biol Lab, Srinagar 190006, Jammu And Kashm, India

[2] Jaipur Natl Univ, Sch Life & Basic Sci, Jaipur 302017, Rajasthan, India

[3] Cent Univ Kashmir, Sch Life Sci, Dept Biotechnol, Srinagar, India

[4] Kashmir Univ, Reg Res Inst Unani Med, Srinagar 190006, India

[5] Sher E Kashmir Univ Agr Sci & Technol, Fac Vet Sci & Anim Husb, Div Vet Pathol, Srinagar 190006, Jammu And Kashm, India

[6] Univ Kashmir, Dept Pharmaceut Sci, Pharmaceut Chem Div, Srinagar 190006, Kashmir, India

来源：

TOXICON | 2024年 / 249卷

关键词：

Acute toxicity; Subacute toxicity; Biochemical analysis; Haematological parameters; Histopathological examination; AQUEOUS EXTRACT; LEAF EXTRACT; LEAVES;

D O I：

10.1016/j.toxicon.2024.108051

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The present study aims to assess the acute and subacute toxicity of the hydro-alcoholic extracts of Anchusa strigosa (leaves) and the aerial parts of Zataria multiflora Boiss in Wistar albino rats. The crude extracts of Anchusa strigosa (leaves) and the aerial parts of Zataria multiflora Boiss were prepared in 70% ethanol. Systematic tests for acute toxicity were performed at varying dosages of 100, 250, and 500 mg/kg, while for subacute toxicity, a dose of 600 mg/kg was orally given to Wistar albino rats. At the end of acute and sub-acute toxicity studies, biochemical parameters, hematological analysis, and histopathological analysis showed no significant difference in the body weight, abnormalities, or organ damage of the rats compared to the untreated rats (control). Also, there were no results of death recorded in rats. These findings indicated that the medium-term oral administration of Anchusa strigosa (leaves) and the aerial parts of Zataria multiflora Boiss after the treatment does not cause toxicity and provides assurance regarding their suitability for potential therapeutic applications in both acute and subacute forms.

引用

页数：11