Sex Differences in Cardiovascular Diseases: Exploring the Role of Microbiota and Immunity

被引：1

作者：

Franza, Laura ^{[1
,2
]}

Caldarelli, Mario ^{[3
,4
]}

Villani, Emanuele Rocco ^{[5
,6
]}

Cianci, Rossella ^{[3
,4
]}

机构：

[1] Fdn Policlin Univ A Gemelli IRCCS Rome, Emergency Anesthesiol & Reanimat Sci Dept, I-00168 Rome, Italy

[2] Azienda Osped Univ Modena, Emergency Dept, Largo Pozzo 71, I-41125 Modena, Italy

[3] Univ Cattolica Sacro Cuore, Dept Translat Med & Surg, I-00168 Rome, Italy

[4] Fdn Policlin Univ A Gemelli, Ist Ricovero & Cura Carattere Sci IRCCS, I-00168 Rome, Italy

[5] Univ Cattolica Sacro Cuore, Dept Geriatr Orthoped & Rheumatol, I-00168 Rome, Italy

[6] AUSL Modena, Dipartimento Cure Primarie, UOC Geriatra Disturbi Cognit & Demenze, I-41012 Modena, Italy

来源：

BIOMEDICINES | 2024年 / 12卷 / 08期

关键词：

cardiovascular diseases; sex differences; gut microbiota; personalized medicine; inflammation; GUT MICROBIOTA; GENE-EXPRESSION; RISK-FACTORS; WOMEN; GENDER; HEALTH; CARDIOMYOPATHY; ASSOCIATIONS; PREVENTION; BIOMARKERS;

D O I：

10.3390/biomedicines12081645

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cardiovascular diseases (CVDs) are the most common cause of mortality and morbidity in Western countries, thus representing a global health concern. CVDs show different patterns in terms of the prevalence and presentation in men and women. The role of sex hormones has been extensively implicated in these sex-specific differences, due to the presence of the menstrual cycle and menopause in women. Moreover, the gut microbiota (GM) has been implicated in cardiovascular health, considering the growing evidence that it is involved in determining the development of specific diseases. In particular, gut-derived metabolites have been linked to CVDs and kidney disorders, which can in turn promote the progression of CVDs. Considering the differences in the composition of GM between men and women, it is possible that gut microbiota act as a mediator in regard to the sex disparities in CVDs. This narrative review aims to comprehensively review the interplay between sex, GM, and CVDs, discussing potential mechanisms and therapeutic options.

引用

页数：21

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