Artificial intelligence and advanced MRI techniques: A comprehensive analysis of diffuse gliomas

Introduction: The complexity of diffuse gliomas relies on advanced imaging techniques like MRI to understand their heterogeneity. Utilizing the UCSF-PDGM dataset, this study harnesses MRI techniques, radiomics, and AI to analyze diffuse gliomas for optimizing patient outcomes. Methods: The research utilized the dataset of 501 subjects with diffuse gliomas through a comprehensive MRI protocol. After performing intricate tumor segmentation, 82.800 radiomic features were extracted for each patient from nine segmentations across eight MRI sequences. These features informed neural network and XGBoost model training to predict patient outcomes and tumor grades, supplemented by SHAP analysis to pinpoint influential radiomic features. Results: In our analysis of the UCSF-PDGM dataset, we observed a diverse range of WHO tumor grades and patient outcomes, discarding one corrupt MRI scan. Our segmentation method showed high accuracy when comparing automated and manual techniques. The neural network excelled in prediction of WHO tumor grades with an accuracy of 0.9500 for the necrotic tumor label. The SHAP-analysis highlighted the 3D First Order mean as one of the most influential radiomic features, with features like Original Shape Sphericity and Original Shape Elongation were notably prominent. Conclusion: A study using the UCSF-PDGM dataset highlighted AI and radiomics' profound impact on neuroradiology by demonstrating reliable tumor segmentation and identifying key radiomic features, despite challenges in predicting patient survival. The research emphasizes both the potential of AI in this field and the need for broader datasets of diverse MRI sequences to enhance patient outcomes.