Overcoming Cancer Resistance: Strategies and Modalities for Effective Treatment

被引：4
作者：
Koirala, Mahesh [1 ]
DiPaola, Mario [1 ]
机构：
[1] Therabene Inc, Norwood, MA 02062 USA
来源：
BIOMEDICINES | 2024年 / 12卷 / 08期
关键词：
cancer drug resistance; targeted protein degradation; immunotherapy combinations; precision medicine; novel drug delivery systems; PROTACs; SNIPERs; combination therapies; CELL LUNG-CANCER; EPITHELIAL-MESENCHYMAL TRANSITION; MULTIDRUG-RESISTANCE; BREAST-CANCER; DRUG-RESISTANCE; MOLECULAR-MECHANISMS; ACQUIRED-RESISTANCE; ESTROGEN-RECEPTOR; GENE-EXPRESSION; P-GLYCOPROTEIN;
D O I：
10.3390/biomedicines12081801
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Resistance to cancer drugs is a complex phenomenon that poses a significant challenge in the treatment of various malignancies. This review comprehensively explores cancer resistance mechanisms and discusses emerging strategies and modalities to overcome this obstacle. Many factors contribute to cancer resistance, including genetic mutations, activation of alternative signaling pathways, and alterations in the tumor microenvironment. Innovative approaches, such as targeted protein degradation, immunotherapy combinations, precision medicine, and novel drug delivery systems, hold promise for improving treatment outcomes. Understanding the intricacies of cancer resistance and leveraging innovative modalities are essential for advancing cancer therapy.
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页数：19
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