Advances in diffuse glioma assessment: preoperative and postoperative applications of chemical exchange saturation transfer

被引:1
作者
Deng, Hua-Zhen [1 ,2 ]
Zhang, Han-Wen [2 ,3 ]
Huang, Biao [3 ]
Deng, Jin-Huan [2 ]
Luo, Si-Ping [2 ]
Li, Wei-Hua [2 ]
Lei, Yi [2 ,4 ]
Liu, Xiao-Lei [2 ]
Lin, Fan [2 ]
机构
[1] Shantou Univ, Med Coll, Shantou City, Peoples R China
[2] Shenzhen Univ, Shenzhen Peoples Hosp 2, Affiliated Hosp 1, Dept Radiol,Hlth Sci Ctr, Shenzhen, Peoples R China
[3] Southern Med Univ, Guangdong Prov Peoples Hosp, Guangdong Acad Med Sci, Dept Radiol, Guangzhou, Guangdong, Peoples R China
[4] Fourth Peoples Hosp Shenzhen, Shenzhen Samii Med Ctr, Dept Radiol, Shenzhen, Peoples R China
关键词
amide proton transfer imaging; adult-type diffuse glioma; preoperative diagnosis; postoperative assessment; precision medicine; CENTRAL-NERVOUS-SYSTEM; HIGH-GRADE GLIOMAS; MRI; CLASSIFICATION; TUMORS; BRAIN;
D O I
10.3389/fnins.2024.1424316
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Chemical Exchange Saturation Transfer (CEST) is a technique that uses specific off-resonance saturation pulses to pre-saturate targeted substances. This process influences the signal intensity of free water, thereby indirectly providing information about the pre-saturated substance. Among the clinical applications of CEST, Amide Proton Transfer (APT) is currently the most well-established. APT can be utilized for the preoperative grading of gliomas. Tumors with higher APTw signals generally indicate a higher likelihood of malignancy. In predicting preoperative molecular typing, APTw values are typically lower in tumors with favorable molecular phenotypes, such as isocitrate dehydrogenase (IDH) mutations, compared to IDH wild-type tumors. For differential diagnosis, the average APTw values of meningiomas are significantly lower than those of high-grade gliomas. Various APTw measurement indices assist in distinguishing central nervous system lesions with similar imaging features, such as progressive multifocal leukoencephalopathy, central nervous system lymphoma, solitary brain metastases, and glioblastoma. Regarding prognosis, APT effectively differentiates between tumor recurrence and treatment effects, and also possesses predictive capabilities for overall survival (OS) and progression-free survival (PFS).
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页数:12
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