Yao syndrome: A potential role and association of vasoactive intestinal peptide with NOD2

被引：2
作者：
Navetta-Modrov, Brianne [1 ]
Ghebrehiwet, Berhane [1 ]
Yao, Qingping [1 ]
机构：
[1] SUNY Stony Brook, Renaissance Sch Med, Dept Med, Div Rheumatol Allergy & Immunol, Stony Brook, NY 11794 USA
来源：
RHEUMATOLOGY AND IMMUNOLOGY RESEARCH | 2021年 / 2卷 / 01期
关键词：
NOD2; NOD2-associated autoinflammatory disease; rash; vasoactive intestinal peptide; Yao syndrome; AUTOINFLAMMATORY DISEASE; PATHWAY;
D O I：
10.2478/rir-2021-0005
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Nucleotide-binding oligomerization domain containing protein 2 (NOD2) is a cytosolic receptor. Both NOD2 and vasoactive intestinal peptide (VIP) are critical in regulation of immune and inflammatory response. Yao syndrome (YAOS, OMIM 617321) is an autoinflammatory disease associated with specified NOD2 mutations. Herein, we report a well-studied case of YAOS masquerading as mast cell disorder and neuroendocrine tumors to support the involvement of VIP in YAOS. For the first time, this case study suggests a potential relationship between NOD2 and VIP. This could provide a novel avenue for mechanistic study of NOD2-associated disease.
引用
收藏
页码：57 / 59
页数：3
相关论文
共 10 条
[1]   Evidence for a role for vasoactive intestinal peptide in active vasodilatation in the cutaneous vasculature of humans [J].
Bennett, LAT ;
Johnson, JM ;
Stephens, DP ;
Saad, AR ;
Kellogg, DL .
JOURNAL OF PHYSIOLOGY-LONDON, 2003, 552 (01) :223-232
[2]   Vasoactive intestinal peptide dampens formyl-peptide-induced ROS production and inflammation by targeting a MAPK-p47phox phosphorylation pathway in monocytes [J].
Chedid, P. ;
Boussetta, T. ;
Dang, P. M-C ;
Belambri, S. A. ;
Marzaioli, V. ;
Fasseau, M. ;
Walker, F. ;
Couvineau, A. ;
El-Benna, J. ;
Marie, J-C .
MUCOSAL IMMUNOLOGY, 2017, 10 (02) :332-340
[3]   The neuropeptide vasoactive intestinal peptide: direct effects on immune cells and involvement in inflammatory and autoimmune diseases [J].
Ganea, D. ;
Hooper, K. M. ;
Kong, W. .
ACTA PHYSIOLOGICA, 2015, 213 (02) :442-452
[4]   Pancreatic neuroendocrine tumors: Clinical features, diagnosis and medical treatment: Advances [J].
Ito, Tetsuhide ;
Igarashi, Hisato ;
Jensen, Robert T. .
BEST PRACTICE & RESEARCH CLINICAL GASTROENTEROLOGY, 2012, 26 (06) :737-753
[5]   Alterations in nucleotide-binding oligomerization domain-2 expression, pathway activation, and cytokine production in Yao syndrome [J].
McDonald, Christine ;
Shen, Min ;
Johnson, Erin E. ;
Kabi, Amrita ;
Yao, Qingping .
AUTOIMMUNITY, 2018, 51 (02) :53-61
[6]   Effectiveness of canakinumab for the treatment of patients with Yao syndrome [J].
Yao, Qingping .
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 2023, 88 (03) :653-654
[7]   A Systematic Analysis of Treatment and Outcomes of NOD2-Associated Autoinflammatory Disease [J].
Yao, Qingping ;
Shen, Bo .
AMERICAN JOURNAL OF MEDICINE, 2017, 130 (03) :365-U186
[8]   NOD2-associated autoinflammatory disease: a large cohort study [J].
Yao, Qingping ;
Shen, Min ;
McDonald, Christine ;
Lacbawan, Felicitas ;
Moran, Rocio ;
Shen, Bo .
RHEUMATOLOGY, 2015, 54 (10) :1904-1912
[9]   Nucleotide-binding oligomerization domain containing 2: Structure, function, and diseases [J].
Yao, Qingping .
SEMINARS IN ARTHRITIS AND RHEUMATISM, 2013, 43 (01) :125-130
[10]   Dermatitis as a characteristic phenotype of a new autoinflammatory disease associated with NOD2 mutations [J].
Yao, Qingping ;
Su, Le-Chu ;
Tomecki, Kenneth J. ;
Zhou, Lan ;
Jayakar, Bijal ;
Shen, Bo .
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 2013, 68 (04) :624-631
1