Yao syndrome: A potential role and association of vasoactive intestinal peptide with NOD2

被引：2
作者：
Navetta-Modrov, Brianne [1 ]
Ghebrehiwet, Berhane [1 ]
Yao, Qingping [1 ]
机构：
[1] SUNY Stony Brook, Renaissance Sch Med, Dept Med, Div Rheumatol Allergy & Immunol, Stony Brook, NY 11794 USA
来源：
RHEUMATOLOGY AND IMMUNOLOGY RESEARCH | 2021年 / 2卷 / 01期
关键词：
NOD2; NOD2-associated autoinflammatory disease; rash; vasoactive intestinal peptide; Yao syndrome; AUTOINFLAMMATORY DISEASE; PATHWAY;
D O I：
10.2478/rir-2021-0005
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Nucleotide-binding oligomerization domain containing protein 2 (NOD2) is a cytosolic receptor. Both NOD2 and vasoactive intestinal peptide (VIP) are critical in regulation of immune and inflammatory response. Yao syndrome (YAOS, OMIM 617321) is an autoinflammatory disease associated with specified NOD2 mutations. Herein, we report a well-studied case of YAOS masquerading as mast cell disorder and neuroendocrine tumors to support the involvement of VIP in YAOS. For the first time, this case study suggests a potential relationship between NOD2 and VIP. This could provide a novel avenue for mechanistic study of NOD2-associated disease.
引用
收藏
页码：57 / 59
页数：3
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