Current Applications of Colorectal Cancer Organoids: A Review

被引：2

作者：

Ban, Quan-Yao ^{[1
]}

Li, Hua-Shan ^{[2
,3
]}

Jiang, Xue-Xue ^{[1
]}

Liu, Mei ^{[1
,2
,3
]}

Ge, Xin-Yao ^{[2
,3
]}

Lu, Mu-Jiao ^{[2
,3
]}

Guo, Shi-Ying ^{[1
]}

Chen, Ying ^{[4
]}

Lin, Qiong ^{[4
]}

Xu, Hong ^{[1
]}

He, Wei-Qi ^{[2
,3
]}

Ding, Ning ^{[2
,3
]}

Zha, Juan -Min ^{[1
]}

机构：

[1] Soochow Univ, Dept Oncol, Affiliated Hosp 1, Suzhou, Jiangsu, Peoples R China

[2] Soochow Univ, Jiangsu Key Lab Neuropsychiat Dis, Suzhou, Jiangsu, Peoples R China

[3] Soochow Univ, Suzhou Med Coll, Genom Resource Ctr, Cambridge Suda CAM SU, Suzhou, Jiangsu, Peoples R China

[4] Jiangnan Univ, Dept Gastroenterol, Affiliated Wuxi Childrens Hosp, Wuxi, Jiangsu, Peoples R China

来源：

JOURNAL OF GASTROINTESTINAL AND LIVER DISEASES | 2024年 / 33卷 / 02期

基金：

中国博士后科学基金; 中国国家自然科学基金;

关键词：

organoid; colorectal cancer; drug screening; personalized medicine; tumor microenvironment; TRANSPLANTATION; CULTURE; MODELS; INSIGHTS; COLON;

D O I：

10.15403/jgld-5388

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Colorectal cancer is a prevalent malignancy, with advanced and metastatic forms exhibiting poor treatment outcomes and high relapse rates. To enhance patient outcomes, a comprehensive understanding of the pathophysiological processes and the development of targeted therapies are imperative. The high heterogeneity of colorectal cancer demands precise and personalized treatment strategies. Colorectal cancer organoids, a three-dimensional in vitro model, have emerged as a valuable tool for replicating tumor biology and exhibit promise in scientific research, disease modeling, drug screening, and personalized medicine. In this review, we present an overview of colorectal cancer organoids and explore their applications in research and personalized medicine, while also discussing potential future developments in this field.

引用

页码：269 / 277

页数：9

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