Exploring the antitumor potential of novel quinoline derivatives via tubulin polymerization inhibition in breast cancer; design, synthesis and molecular docking

被引:2
|
作者
Abdelmegeed, Heba [1 ]
Abdel Ghany, Lina M. A. [2 ]
Youssef, Amira [3 ]
El-Etrawy, Abd-Allah S. [3 ,4 ]
Ryad, Noha [3 ]
机构
[1] Natl Res Ctr, Pharmaceut & Drug Ind Res Inst, Chem Nat Cpds Dept, Giza 12622, Egypt
[2] Misr Univ Sci & Technol MUST, Coll Pharmaceut Sci & Drug Mfg, Pharmaceut Chem Dept, POB 77,6th October City, Giza, Egypt
[3] Misr Univ Sci & Technol MUST, Pharmaceut Organ Chem, Coll Pharmaceut Sci & Drug Mfg, POB 77,6th October City, Giza, Egypt
[4] Misr Univ Sci & Technol MUST, Dept Chem, Basic Sci, POB 77,6th October City, Giza, Egypt
关键词
COLCHICINE-BINDING-SITE; COMBRETASTATIN A-4; DIVERSE SET; PHARMACOPHORE; APOPTOSIS; DISCOVERY; ANALOGS; AGENTS;
D O I
10.1039/d4ra04371e
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
A series of quinoline derivatives was designed and synthesized as novel tubulin inhibitors targeting the colchicine binding site. All the rationalized compounds 3a-e, 4a-e, 5a-e, and 6a-e have been chosen for screening their cytotoxic activity against 60 cell lines by NCI. Compounds 3b, 3c, 4c, 5c and 6c demonstrated the most notable antitumor activity against almost all cell lines. Compound 4c emerged as the most potent compound as an antiproliferative agent. This compound was subsequently chosen for five-dose testing and it exhibited remarkable broad-spectrum efficacy with strong antitumor activity against several cell lines. Compound 4c significantly induced cell cycle arrest in MDA-MB-231 cells at G2 and M phases where the cell population increased dramatically to 22.84% compared to the untreated cells at 10.42%. It also increased the population in MDA-MB-231 cells at both early and late stages of apoptosis. Compound 4c can successfully inhibit tubulin polymerization with an IC50 value of 17 +/- 0.3 mu M. The beta-tubulin mRNA levels were notably reduced in MDA-MB-231 cells treated with compound 4c which is similar to the effect observed with colchicine treatment. Docking studies revealed that compound 4c interacted well with crucial amino acids in the active site.
引用
收藏
页码:22092 / 22112
页数:21
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