Embryonic and larval zebrafish models for the discovery of new bioactive compounds against tuberculosis

被引：0

作者：

Antunes, Stella S. ^{[1
]}

Forn-Cuni, Gabriel ^{[2
]}

Romeiro, Nelilma C. ^{[1
]}

Spaink, Herman P. ^{[2
]}

Verbeek, Fons J. ^{[3
]}

Muzitano, Michelle F. ^{[1
]}

机构：

[1] Univ Fed Rio de Janeiro, Inst Pharmaceut Sci, Rio De Janeiro, Brazil

[2] Leiden Univ, Inst Biol Leiden, Leiden, Netherlands

[3] Leiden Univ, Leiden Inst Adv Comp Sci, Leiden, Netherlands

来源：

DRUG DISCOVERY TODAY | 2024年 / 29卷 / 11期

关键词：

tuberculosis; zebra fish; Mycobacterium marinum; drug discovery; GYRASE ATPASE DOMAIN; MYCOBACTERIUM-TUBERCULOSIS; LEAD OPTIMIZATION; KINASE INHIBITORS; TOXICITY; DESIGN; CARDIOTOXICITY; ANTIBACTERIAL; VISUALIZATION; NANOPARTICLES;

D O I：

10.1016/j.drudis.2024.104163

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Tuberculosis (TB) is a world health challenge the treatment of which is impacted by the rise of drugresistant strains. Thus, there is an urgent need for new antitubercular compounds and novel approaches to improve current TB therapy. The zebrafish animal model has become increasingly relevant as an experimental system. It has proven particularly useful during early development for aiding TB drug discovery, supporting both the discovery of new insights into mycobacterial pathogenesis and the evaluation of therapeutical toxicity and efficacy in vivo. In this review, we summarize the past two decades of zebrafish-Mycobacterium marinum research and discuss its contribution to the field of bioactive antituberculosis therapy development.

引用

页数：11

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