Chinese herbal medicine compound of flavonoids adjunctive treatment for oral cancer

被引:5
|
作者
Huang, Yi-Chao [1 ,3 ]
Sung, Min-Yi [2 ,3 ]
Lin, Tsung-Kun [4 ,5 ]
Kuo, Chan-Yen [6 ]
Hsu, Yi-Chiung [3 ,7 ]
机构
[1] Natl Def Med Ctr, Hlth Serv Training Ctr HSTC, Taipei, Taiwan
[2] Buddhist Tzu Chi Med Fdn, Taipei Tzu Chi Hosp, Dept Dent, New Taipei City, Taiwan
[3] Natl Cent Univ, Dept Biomed Sci & Engn, Taoyuan, Taiwan
[4] Natl Def Med Ctr, Sch Pharm, Taipei, Taiwan
[5] MND, Med Affairs Bur, Pharmaceut Management Div, Taipei, Taiwan
[6] Taipei Tzu Chi Hosp, Buddhist Tzu Chi Med Fdn, Dept Res, New Taipei City, Taiwan
[7] Natl Cent Univ, Ctr Astronaut Phys & Engn, Taoyuan, Taiwan
关键词
Oral cancer; Chemotherapy; Chinese herbal medicine; Flavonoid; Adjuvant treatment; SQUAMOUS-CELL CARCINOMA; NF-KAPPA-B; E-CADHERIN; EXPRESSION; APOPTOSIS; GROWTH; PROTEINS; GENE; HEAD; P53;
D O I
10.1016/j.jfma.2023.10.009
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Oral cancer is a prevalent global issue, with oral squamous cell carcinoma constituting the majority of cases. Standard treatments like surgery, radiotherapy, and chemotherapy are available but may have adverse effects. Molecular gene therapy, focusing on genetic mutations linked to oral cancer, presents a promising alternative.In this study, we evaluated 27 chemotherapeutic drugs and 63 Chinese herbal medicines for their effectiveness, categorized them by their cellular mechanisms, and identified potential adjuvant therapy candidates for oral cancer. Our findings highlight the impact of natural flavonoids on oral cancer cells, inducing apoptosis, and confirming their potential in molecular genetic analysis. In conclusion, the natural compounds present in Chinese herbal medicine, particularly flavonoids, offer a promising avenue to target specific genetic mutations in oral cancer cells. This approach may reduce the risks associated with oral cancer treatment and pave the way for innovative adjuvant therapies.
引用
收藏
页码:830 / 836
页数:7
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