Glymphatic System and Psychiatric Disorders: A Rapid Comprehensive Scoping Review

被引：4

作者：

Barlattani, Tommaso ^{[1
]}

Grandinetti, Paolo ^{[2
]}

Di Cintio, Alexsander ^{[1
]}

Montemagno, Alessio ^{[1
]}

Testa, Roberta ^{[2
]}

D'Amelio, Chiara ^{[1
]}

Olivieri, Luigi ^{[2
]}

Tomasetti, Carmine ^{[2
]}

Rossi, Alessandro ^{[1
]}

Pacitti, Francesca ^{[1
]}

De Berardis, Domenico ^{[2
]}

机构：

[1] Univ LAquila, Dept Biotechnol & Appl Clin Sci DISCAB, Via Vetoio, I-67100 LAquila, Italy

[2] Hosp G Mazzini, Dept Mental Hlth Psychiat Serv Diag & Treatment, Natl Hlth Serv, ASL 4, Teramo, Italy

来源：

CURRENT NEUROPHARMACOLOGY | 2024年 / 22卷 / 12期

关键词：

Glymphatic system; aquaporin-4; astrocytes; psychiatric disorders; mood disorders; depression; CEREBROSPINAL-FLUID; BIPOLAR DISORDER; RISK-FACTOR; INTERSTITIAL FLUID; ALZHEIMERS-DISEASE; SLEEP-DEPRIVATION; OXIDATIVE STRESS; DEPRESSION; SCHIZOPHRENIA; EXPRESSION;

D O I：

10.2174/1570159X22666240130091235

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Background Since discovering the glymphatic system, there has been a looming interest in exploring its relationship with psychiatric disorders. Recently, increasing evidence suggests an involvement of the glymphatic system in the pathophysiology of psychiatric disorders. However, clear data are still lacking. In this context, this rapid comprehensive PRISMA-ScR (Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews) scoping review aims to identify and analyze current evidence about the relation between the glymphatic system and psychiatric disorders.Methods We conducted a comprehensive review of the literature and then proceeded to discuss the findings narratively. Tables were then constructed and articles were sorted according to authors, year, title, location of study, sample size, psychiatric disorder, the aim of the study, principal findings, implications.Results Twenty papers were identified as eligible, among which 2 articles on Schizophrenia, 1 on Autism Spectrum Disorders, 2 on Depression, 1 on Depression and Trauma-related Disorders, 1 on Depression and Anxiety, 2 on Anxiety and Sleep Disorders, 8 on Sleep Disorders, 2 on Alcohol use disorder and 1 on Cocaine Use Disorder.Conclusion This review suggests a correlation between the glymphatic system and several psychiatric disorders: Schizophrenia, Depression, Anxiety Disorders, Sleep Disorders, Alcohol Use Disorder, Cocaine Use Disorder, Trauma-Related Disorders, and Autism Spectrum Disorders. Impairment of the glymphatic system could play a role in Trauma-Related Disorders, Alcohol Use Disorders, Cocaine Use Disorders, Sleep Disorders, Depression, and Autism Spectrum Disorders. It is important to implement research on this topic and adopt standardized markers and radio diagnostic tools.

引用

页码：2016 / 2033

页数：18

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