Innate and Adaptive Immune Responses in Intestinal Transplant Rejection Through the Lens of Inflammatory Bowel and Intestinal Graft-Versus-Host Diseases

被引：0

作者：

Cui, Yuki ^{[1
,2
]}

Hackett, Ryan G. ^{[1
,2
]}

Ascue, Jhalen ^{[1
,2
]}

Muralidaran, Vinona ^{[1
,2
]}

Patil, Digvijay ^{[1
,2
]}

Kang, Jiman ^{[1
,2
,3
]}

Kaufman, Stuart S. ^{[1
,2
]}

Khan, Khalid ^{[1
,2
]}

Kroemer, Alexander ^{[1
,2
]}

机构：

[1] MedStar Georgetown Univ Hosp, MedStar Georgetown Transplant Inst, Washington, DC USA

[2] Georgetown Univ, Ctr Translat Transplant Med, Med Ctr, Washington, DC USA

[3] Georgetown Univ, Dept Biochem & Mol & Cellular Biol, Washington, DC 20007 USA

来源：

GASTROENTEROLOGY CLINICS OF NORTH AMERICA | 2024年 / 53卷 / 03期

基金：

美国国家卫生研究院;

关键词：

Intestine; Transplantation; Rejection; Immunity; Innate; Adaptive; GvHD; IBD; REGULATORY T-CELLS; DONOR-SPECIFIC ANTIBODIES; NATURAL-KILLER-CELLS; LYMPHOID-CELLS; ALLOGRAFT-REJECTION; DENDRITIC CELLS; TH17; CELLS; ISCHEMIA-REPERFUSION; HELPER; 17; MACROPHAGES;

D O I：

10.1016/j.gtc.2024.01.002

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

lymphoid cells (ILC)1s and the regulatory interleukin IL-22 from ILC3s plays a critical role in modulating the immune response in intestinal transplant. Furthermore, natural killer cells may contribute to either rejection or tolerance in intestinal transplant via the acti. For adaptive immunity, intestinal transplantation rejection is primarily driven by proinflam. Elevated ILC1/ILC3 and Th17/Treg population ratios and the plasticity of these cell types

引用

页码：359 / 382

页数：24

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