Ethyl acetate extract of Nymphaea candida Presl: A potential anti-depressant and neuroprotective treatment strategy

被引:0
作者
Hong, Huixia [1 ,2 ]
Gao, Ming [1 ,2 ]
Zhou, Min [1 ,2 ]
Wang, Ao [1 ,2 ]
Hua, Ruimao [1 ,2 ]
Ma, Ziwei [3 ]
Wang, Yachao [4 ,5 ]
Xu, Yanwen [6 ]
Bai, Yu [3 ]
Huang, Guodong [4 ,5 ]
Yu, Yuming [1 ,2 ]
Tan, Hui [3 ]
机构
[1] Xinjiang Univ, Coll Chem, Urumqi 830017, Xinjiang, Peoples R China
[2] Xinjiang Univ, State Key Lab Chem & Utilizat Carbon Based Energy, Urumqi 830017, Xinjiang, Peoples R China
[3] Shenzhen Univ, Shantou Univ, Shenzhen Childrens Hosp, Shenzhen Peoples Hosp 2,Med Coll,Hlth Sci Ctr, Shenzhen 518026, Peoples R China
[4] Shenzhen Univ, Shenzhen Peoples Hosp 2, Affiliated Hosp 1, Dept Neurosurg, Shenzhen 518035, Peoples R China
[5] Shenzhen Univ, Affiliated Hosp 1, Shenzhen Peoples Hosp 2, Shenzhen Inst Translat Med, Shenzhen, Peoples R China
[6] Shenzhen Univ, Shenzhen Peoples Hosp 2, Affiliated Hosp 1, Translat Med Inst,Hlth Sci Ctr, Shenzhen 518035, Guangdong, Peoples R China
关键词
Nymphaea candida Presl; depression; lipopolysaccharide; hippocampus; neuroprotection; PC12; ANTIDEPRESSANTS; BEHAVIOR; ANXIETY; STRESS;
D O I
10.1016/j.biopha.2024.117304
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Nymphaea candida Presl (NC), traditionally used in medicine for heat syndrome-related ailments, possesses antioxidative, anti-inflammatory, hepatoprotective, and neuroprotective properties. This research investigates the antidepressant and neuroprotective effects and mechanisms of Nymphaea candida Presl ethyl acetate (NCEA). Primary components of NCEA were identified as phenolic acids and flavonoids through UPLC-MS/MS analysis. The depression mouse model was induced via intracerebroventricular injection of Lipopolysaccharide (LPS), followed by oral administration of fluoxetine and NCEA for one week. Biochemical assays and HE staining confirmed NCEA's non-toxicity and protective effects on the liver and lungs. NCEA administration mitigated LPSinduced depressive behaviors, decreased IL-1 beta, TNF-alpha levels in the hippocampus, suppressed microglial activation, reduced Iba-1 expression, and increased NA, brain-derived neurotrophic factor (BDNF), and dendritic spine density in the hippocampus. Furthermore, NCEA enhanced cell viability in a CORT-induced PC12 cell model, decreased lactate dehydrogenase (LDH) release rate, total superoxide dismutase (SOD) inhibition rate, intracellular nitric oxide (NO) release, and reduced reactive oxygen species (ROS) production. Our research findings suggest that NCEA exhibits significant antidepressant effects, which may be attributed to its reduction of neuroinflammation, improvement in neurotransmitter levels, neuronal protection, and antioxidative stress properties.
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页数:14
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