Current trends in silica based drug delivery systems

被引：9
作者：
Khoz, Rozhan [1 ]
Yazdian, Fateme [1 ]
Pourmadadi, Mehrab [2 ]
Rahdar, Abbas [3 ]
Fathi-karkan, Sonia [4 ,5 ]
Pandey, Sadanand [6 ]
机构：
[1] Univ Tehran, Coll Interdisciplinary Sci & Technol, Fac Life Sci Engn, Tehran, Iran
[2] Shahid Beheshti Univ, Prot Res Ctr, Tehran 1983963113, GC, Iran
[3] Univ Zabol, Dept Phys, POB 98613-35856, Zabol, Iran
[4] North Khorasan Univ Med Sci, Nat Prod & Med Plants Res Ctr, Bojnurd 9453155166, Iran
[5] North Khorasan Univ Med Sci, Sch Med, Dept Adv Sci & Technol Med, Bojnurd 9414974877, Iran
[6] Shoolini Univ, Fac Appl Sci & Biotechnol, Sch Bioengn & Food Technol, Solan 173229, Himachal Prades, India
来源：
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY REPORTS | 2024年 / 12卷
关键词：
Drug delivery systems; Silica; Mesoporous silica nanoparticles; Biomedical applications; SiO2; MANGANESE OXIDE NANOPARTICLES; MAGNETIC-RESONANCE; PHARMACEUTICAL APPLICATIONS; FABRICATION; SURFACTANT; PLATFORM; DEXAMETHASONE; NANOMATERIAL; FLUORESCENT; RELEASE;
D O I：
10.1016/j.ejmcr.2024.100206
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Traditional drug delivery systems have fallen short in addressing the complex medical and therapeutic needs of patients, necessitating the development of more efficient alternatives. These novel systems aim to enhance treatment efficacy while minimizing adverse effects. Advances in drug delivery technology have significantly improved drug loading and release, administration methods, pharmacological profiles, and the creation of innovative drug formulations. This review delves into current methodologies employed in silica-based targeted drug delivery systems. After examining the structure and properties of various silicas, we focus on mesoporous nanoparticles for targeted drug delivery, exploring existing approaches and addressing critical concerns such as silica safety and biodegradability. Additionally, this review provides a brief overview of bioassays, cell tracking, and tumor-specific targeting strategies.
引用
收藏
页数：10
相关论文
共 115 条
[111]   Functionalized Mesoporous Silica Nanoparticles with Mucoadhesive and Sustained Drug Release Properties for Potential Bladder Cancer Therapy [J].
Zhang, Quan ;
Neoh, Koon Gee ;
Xu, Liqun ;
Lu, Shengjie ;
Kang, En Tang ;
Mahendran, Ratha ;
Chiong, Edmund .
LANGMUIR, 2014, 30 (21) :6151-6161
[112]   Chemically engineered mesoporous silica nanoparticles-based intelligent delivery systems for theranostic applications in multiple cancerous/non-cancerous diseases [J].
Zhou, Shuai ;
Zhong, Qin ;
Wang, Yang ;
Hu, Po ;
Zhong, Wei ;
Huang, Chao-Bo ;
Yu, Zhi-Qiang ;
Ding, Chen-Di ;
Liu, Hongxing ;
Fu, Jiajun .
COORDINATION CHEMISTRY REVIEWS, 2022, 452
[113]   Mesoporous silica nanoparticles/gelatin porous composite scaffolds with localized and sustained release of vancomycin for treatment of infected bone defects [J].
Zhou, Xiaojun ;
Weng, Weizong ;
Chen, Bo ;
Feng, Wei ;
Wang, Weizhong ;
Nie, Wei ;
Chen, Liang ;
Mo, Xiumei ;
Su, Jiacan ;
He, Chuanglong .
JOURNAL OF MATERIALS CHEMISTRY B, 2018, 6 (05) :740-752
[114]   BMP-2 Derived Peptide and Dexamethasone Incorporated Mesoporous Silica Nanoparticles for Enhanced Osteogenic Differentiation of Bone Mesenchymal Stem Cells [J].
Zhou, Xiaojun ;
Feng, Wei ;
Qiu, Kexin ;
Chen, Liang ;
Wang, Weizhong ;
Nie, Wei ;
Mo, Xiumei ;
He, Chuanglong .
ACS APPLIED MATERIALS & INTERFACES, 2015, 7 (29) :15777-15789
[115]   Multi-functional silica-based mesoporous materials for simultaneous delivery of biologically active ions and therapeutic biomolecules [J].
Zhu, Hui ;
Zheng, Kai ;
Boccaccini, Aldo R. .
ACTA BIOMATERIALIA, 2021, 129 :1-17
3456789101112