Design strategies, advances and future perspectives of colon-targeted delivery systems for the treatment of inflammatory bowel disease

被引：12

作者：

Zheng, Baoxin ^{[1
]}

Wang, Liping ^{[1
]}

Yi, Yan ^{[1
]}

Yin, Jun ^{[2
]}

Liang, Aihua ^{[1
]}

机构：

[1] China Acad Chinese Med Sci, Inst Chinese Mat Med, Key Lab Beijing Identificat & Safety Evaluat Chine, Beijing 100700, Peoples R China

[2] Shenyang Pharmaceut Univ, Sch Tradit Chinese Mat, Shenyang 110016, Peoples R China

来源：

ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES | 2024年 / 19卷 / 04期

基金：

中国博士后科学基金; 中国国家自然科学基金;

关键词：

Colon-targeted drug delivery system; Inflammatory bowel disease; Design strategy; Treatment mechanism; Advanced complementary therapy; DOUBLE-EDGED-SWORD; CHAIN FATTY-ACIDS; DRUG-DELIVERY; GASTROINTESTINAL-TRACT; MAINTENANCE THERAPY; ULCERATIVE-COLITIS; CONTROLLED-RELEASE; GUAR GUM; NANOPARTICLES; RECEPTOR;

D O I：

10.1016/j.ajps.2024.100943

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Inflammatory bowel diseases (IBD) significantly contribute to high mortality globally and negatively affect patients' qualifications of life. The gastrointestinal tract has unique anatomical characteristics and physiological environment limitations. Moreover, certain natural or synthetic anti-inflammatory drugs are associated with poor targeting, low drug accumulation at the lesion site, and other side effects, hindering them from exerting their therapeutic effects. Colon-targeted drug delivery systems represent attractive alternatives as novel carriers for IBD treatment. This review mainly discusses the treatment status of IBD, obstacles to drug delivery, design strategies of colon-targeted delivery systems, and perspectives on the existing complementary therapies. Moreover, based on recent reports, we summarized the therapeutic mechanism of colon-targeted drug delivery. Finally, we addressed the challenges and future directions to facilitate the exploitation of advanced nanomedicine for IBD therapy. (c) 2024 Shenyang Pharmaceutical University. Published by Elsevier B.V. ( http://creativecommons.org/licenses/by-nc-nd/4.0/ )

引用

页数：29

共 192 条

[1]

Alavi M, 2017, ADV PHARM BULL, V7, P3, DOI 10.15171/apb.2017.002

[2] Alginate-polyvinyl alcohol based interpenetrating polymer network for prolonged drug therapy, Optimization and in-vitro characterization [J].

Anwar, Hina ;

Ahmad, Mahmood ;

Minhas, Muhammad Usman ;

Rehmani, Sahrish .

CARBOHYDRATE POLYMERS, 2017, 166 :183-194

[3] Clinical translation of advanced colonic drug delivery technologies [J].

Awad, Atheer ;

Madla, Christine M. ;

McCoubrey, Laura E. ;

Ferraro, Fabiana ;

Gavins, Francesca K. H. ;

Buanz, Asma ;

Gaisford, Simon ;

Orlu, Mine ;

Siepmann, Florence ;

Siepmann, Juergen ;

Basit, Abdul W. .

ADVANCED DRUG DELIVERY REVIEWS, 2022, 181

[4] Efficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine [J].

Baden, Lindsey R. ;

El Sahly, Hana M. ;

Essink, Brandon ;

Kotloff, Karen ;

Frey, Sharon ;

Novak, Rick ;

Diemert, David ;

Spector, Stephen A. ;

Rouphael, Nadine ;

Creech, C. Buddy ;

McGettigan, John ;

Khetan, Shishir ;

Segall, Nathan ;

Solis, Joel ;

Brosz, Adam ;

Fierro, Carlos ;

Schwartz, Howard ;

Neuzil, Kathleen ;

Corey, Larry ;

Gilbert, Peter ;

Janes, Holly ;

Follmann, Dean ;

Marovich, Mary ;

Mascola, John ;

Polakowski, Laura ;

Ledgerwood, Julie ;

Graham, Barney S. ;

Bennett, Hamilton ;

Pajon, Rolando ;

Knightly, Conor ;

Leav, Brett ;

Deng, Weiping ;

Zhou, Honghong ;

Han, Shu ;

Ivarsson, Melanie ;

Miller, Jacqueline ;

Zaks, Tal .

NEW ENGLAND JOURNAL OF MEDICINE, 2021, 384 (05) :403-416

[5] Macrophages in intestinal homeostasis and inflammation [J].

Bain, Calum C. ;

Mowat, Allan McI .

IMMUNOLOGICAL REVIEWS, 2014, 260 (01) :102-117

[6] Exosomes: Therapy delivery tools and biomarkers of diseases [J].

Barile, Lucio ;

Vassalli, Giuseppe .

PHARMACOLOGY & THERAPEUTICS, 2017, 174 :63-78

[7] Metal-Organic Framework-Templated Biomaterials: Recent Progress in Synthesis, Functionalization, and Applications [J].

Begum, Salma ;

Hassan, Zahid ;

Braese, Stefan ;

Woell, Christof ;

Tsotsalas, Manuel .

ACCOUNTS OF CHEMICAL RESEARCH, 2019, 52 (06) :1598-1610

[8] Starch digestibility: past, present, and future [J].

Bello-Perez, Luis A. ;

Flores-Silva, Pamela C. ;

Agama-Acevedo, Edith ;

Tovar, Juscelino .

JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE, 2020, 100 (14) :5009-5016

[9] Biologic Therapy for Ulcerative Colitis [J].

Bhattacharya, Abhik ;

Osterman, Mark Tomislav .

GASTROENTEROLOGY CLINICS OF NORTH AMERICA, 2020, 49 (04) :717-+

[10] Oxidative Stress and Redox-Modulating Therapeutics in Inflammatory Bowel Disease [J].

Bourgonje, Arno R. ;

Feelisch, Martin ;

Faber, Klaas Nico ;

Pasch, Andreas ;

Dijkstra, Gerard ;

van Goor, Harry .

TRENDS IN MOLECULAR MEDICINE, 2020, 26 (11) :1034-1046

← 1 2 3 4 5 6 7 8 9 10 →