Methemoglobin in critically ill septic patients

被引：0

作者：

Phongphithakchai, Atthaphong ^{[1
,2
]}

Maeda, Akinori ^{[1
]}

Hikasa, Yukiko ^{[1
]}

Spano, Sofia ^{[1
]}

Pattamin, Nuttapol ^{[1
]}

Chaba, Anis ^{[1
]}

Eastwood, Glenn ^{[1
,3
,4
]}

Young, Helen ^{[1
]}

Peck, Leah ^{[1
]}

Bellomo, Rinaldo ^{[1
,3
,4
,5
,6
]}

机构：

[1] Austin Hosp, Dept Intens Care, Melbourne, Vic, Australia

[2] Prince Songkla Univ, Fac Med, Dept Internal Med, Div Nephrol, Hat Yai, Songkhla, Thailand

[3] Univ Melbourne, Dept Crit Care, Melbourne, Vic, Australia

[4] Monash Univ, Australian & New Zealand Intens Care Res Ctr, Melbourne, Vic, Australia

[5] Austin Hosp, Data Analyt Res & Evaluat Ctr, Melbourne, Vic, Australia

[6] Royal Melbourne Hosp, Dept Intens Care, Melbourne, Vic, Australia

来源：

BIOMARKERS IN MEDICINE | 2024年 / 18卷 / 19期

关键词：

biomarker; ICU mortality; lactate; methemoglobin; nitric oxide; sepsis; NITRIC-OXIDE OVERPRODUCTION; DOUBLE-BLIND; SEPSIS; 546C88; SHOCK;

D O I：

10.1080/17520363.2024.2395246

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Aim: Higher nitric oxide (NO) levels correlate with adverse sepsis outcomes but are challenging to measure. Methemoglobin (MetHb), a measurable product of NO, has not been utilized for risk stratification. Methodology: All patients with sepsis admitted to the intensive care unit (ICU) that had at least one MetHb measurement within 24 h of ICU admission were retrospectively analyzed. We assessed the epidemiology and associations of MetHb with hospital mortality. Results: Among 7724 patients, 1046 qualified. Those with MetHb >= 1.6% showed significantly higher mortality and fewer days alive outside the hospital by day 28. MetHb levels >= 1.6% independently predicted increased 28-day mortality. Conclusion: Our findings suggest MetHb, easily obtainable from arterial blood gases, can significantly enhance sepsis risk stratification.

引用

页码：823 / 830

页数：8

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