Epigenetic regulation of diverse regulated cell death modalities in cardiovascular disease: Insights into necroptosis, pyroptosis, ferroptosis, and cuproptosis

被引:18
作者
Chen, Cong [1 ]
Wang, Jie [1 ]
Zhang, Shan [2 ]
Zhu, Xueying [3 ]
Hu, Jun [1 ]
Liu, Chao [1 ]
Liu, Lanchun [1 ]
机构
[1] China Acad Chinese Med Sci, Guanganmen Hosp, Dept Cardiol, Beijing 100053, Peoples R China
[2] China Acad Chinese Med Sci, Guanganmen Hosp, Dept Endocrinol, Beijing 100053, Peoples R China
[3] Beijing Univ Chinese Med, Sch Tradit Chinese Med, Dept Anat, Beijing 102488, Peoples R China
基金
中国国家自然科学基金;
关键词
Epigenetic modification; Necroptosis; Pyroptosis; Ferroptosis; Cuproptosis; ISCHEMIA-REPERFUSION INJURY; INDUCED CARDIAC FIBROSIS; MYOCARDIAL ISCHEMIA/REPERFUSION INJURY; ABDOMINAL AORTIC-ANEURYSM; HYPOXIA-INDUCED APOPTOSIS; HEART-FAILURE; NLRP3; INFLAMMASOME; CARDIOMYOCYTE PYROPTOSIS; DOWN-REGULATION; CORONARY MICROEMBOLIZATION;
D O I
10.1016/j.redox.2024.103321
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Cell death constitutes a critical component of the pathophysiology of cardiovascular diseases. A growing array of non-apoptotic forms of regulated cell death (RCD)-such as necroptosis, ferroptosis, pyroptosis, and cuproptosis-has been identified and is intimately linked to various cardiovascular conditions. These forms of RCD are governed by genetically programmed mechanisms within the cell, with epigenetic modifications being a common and crucial regulatory method. Such modifications include DNA methylation, RNA methylation, histone methylation, histone acetylation, and non-coding RNAs. This review recaps the roles of DNA methylation, RNA methylation, histone modifications, and non-coding RNAs in cardiovascular diseases, as well as the mechanisms by which epigenetic modifications regulate key proteins involved in cell death. Furthermore, we systematically catalog the existing epigenetic pharmacological agents targeting novel forms of RCD and their mechanisms of action in cardiovascular diseases. This article aims to underscore the pivotal role of epigenetic modifications in precisely regulating specific pathways of novel RCD in cardiovascular diseases, thus offering potential new therapeutic avenues that may prove more effective and safer than traditional treatments.
引用
收藏
页数:37
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