Residual dipolar couplings as a tool in determining the structure of organic molecules

被引：144

作者：

Kummerloewe, Grit ^{[1
]}

Luy, Burkhard ^{[1
]}

机构：

[1] Tech Univ Munich, Dept Chem, LS OC II, D-85747 Garching, Germany

来源：

TRAC-TRENDS IN ANALYTICAL CHEMISTRY | 2009年 / 28卷 / 04期

关键词：

Alignment media; Chirality; Configuration; Conformation; NMR spectroscopy; Nuclear magnetic resonance; Organic molecule; RDC; Residual dipolar coupling; Structure; NMR ALIGNMENT MEDIA; LONG-RANGE SCALAR; ONE-BOND; STRUCTURE ELUCIDATION; GELS; SPECTROSCOPY; SOLVENTS; STEREOCHEMISTRY; RDCS; ENANTIOMERS;

D O I：

10.1016/j.trac.2008.11.016

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

In the past decade, residual dipolar couplings (RDCs) have revolutionized biomolecular nuclear magnetic resonance spectroscopy. Recent developments indicate that this technique can also be applied successfully to organic molecules to determine conformation and configuration, and to distinguish enantiomers. We briefly introduce the basic principle of the method, available alignment media, and pulse sequences for measuring RDCs. We also give an overview of potential applications. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：483 / 493

页数：11

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