Crosstalk between histone/DNA modifications and RNA N6-methyladenosine modification

被引：3
作者：
Wang, Yushuai [1 ]
Huang, Huilin [2 ]
Chen, Jianjun [3 ,4 ]
Weng, Hengyou [1 ,5 ,6 ]
机构：
[1] Guangzhou Natl Lab, Guangzhou 510005, Peoples R China
[2] Sun Yat Sen Univ Canc Ctr, Collaborat Innovat Ctr Canc Med, State Key Lab Oncol South China, Guangzhou 510060, Peoples R China
[3] Beckman Res Inst City Hope, Dept Syst Biol, Monrovia, CA 91016 USA
[4] Comprehensive Canc Ctr City Hope, Gehr Family Ctr Leukemia Res & City Hope Comprehen, Duarte, CA 91010 USA
[5] Guangzhou Regenerat Med & Hlth Guangdong Lab, Bioland Lab, Guangzhou 510005, Peoples R China
[6] Guangzhou Med Univ, Affiliated Hosp 1, State Key Lab Resp Dis, Guangzhou 510120, Peoples R China
来源：
CURRENT OPINION IN GENETICS & DEVELOPMENT | 2024年 / 86卷
基金：
美国国家卫生研究院; 中国国家自然科学基金; 国家重点研发计划;
关键词：
GENE-EXPRESSION; N-6-METHYLADENOSINE RNA; M(6)A RNA; STRUCTURAL BASIS; NUCLEAR-RNA; METHYLATION; CHROMATIN; METABOLISM; RECOGNITION; TRANSLATION;
D O I：
10.1016/j.gde.2024.102205
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
N6-methyladenosine 6-methyladenosine (m6A) 6 A) is the most prevalent internal RNA modification in eukaryotic messenger RNAs (mRNAs), regulating gene expression at the transcription and post- transcription levels. Complex interplay between m6A 6 A and other well-studied epigenetic modifications, including histone modifications and DNA modification, has been extensively reported in recent years. The crosstalk between RNA m6A 6 A modification and histone/DNA modifications plays a critical role in establishing the chromatin state for the precise and specific fine-tuning of gene expression and undoubtedly has profound impacts on both physiological and pathological processes. In this review, we discuss the crosstalk between RNA m6A 6 A modification and histone/DNA modifications, emphasizing their sophisticated communications and the mechanisms underlying to gain a comprehensive view of the biological relevance of m6A-based 6 A-based epigenetic network.
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页数：7
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