Palladium-Catalyzed Four-Component Radical Cascade Carbonylation Access to 2,3-Disubstituted Benzofuran Derivatives

被引：6

作者：

Li, Ming ^{[1
]}

Miao, Dong-Yu ^{[1
]}

Gao, Fan ^{[1
]}

Xu, Shanmei ^{[1
]}

Li, Shun-Xi ^{[1
]}

Chen, Dong-Ping ^{[1
]}

Qiu, Yi-Feng ^{[1
]}

Quan, Zheng-Jun ^{[1
]}

Wang, Xi-Cun ^{[1
]}

Liang, Yong-Min ^{[2
]}

机构：

[1] Northwest Normal Univ, Coll Chem & Chem Engn, Gansu Int Sci & Technol Cooperat Base Water Retent, Lanzhou 730070, Gansu, Peoples R China

[2] Lanzhou Univ, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China

来源：

ORGANIC LETTERS | 2024年 / 26卷 / 39期

基金：

中国国家自然科学基金;

关键词：

CYCLIZATION; ACTIVATION; 1,6-ENYNES; ARYLATION; ANILINES; CO;

D O I：

10.1021/acs.orglett.4c02960

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Multicomponent radical tandem reactions have emerged as a crucial technique for synthesizing complex molecules in organic chemistry. In this study, we report a palladium-catalyzed four-component difluoroalkylative carbonylation of enynes and ethyl difluoroiodoacetate. This transformation proceeds through a multistep sequential reaction that introduces reactive difluoro and carbonyl groups while constructing the benzofuran skeleton. Moreover, a variety of valuable 2,3-disubstituted benzofuran derivatives were obtained in respectable yields with excellent functional group compatibility.

引用

收藏

页码：8289 / 8294

页数：6

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