A comprehensive review of natural product-derived compounds acting on P2X7R: The promising therapeutic drugs in disorders

被引：2
作者：
Liu, Zhenling [1 ]
Liu, Wenjin [2 ]
Han, Mengyao [2 ]
Wang, Mingzhu [1 ]
Li, Yinchao [2 ]
Yao, Yongfang [2 ,3 ,4 ]
Duan, Yongtao [1 ,5 ,6 ]
机构：
[1] Zhengzhou Univ, Childrens Hosp, Zhengzhou 450018, Peoples R China
[2] Zhengzhou Univ, Sch Pharmaceut Sci, Zhengzhou 450001, Peoples R China
[3] Zhengzhou Univ, Pingyuan Lab, Zhengzhou 450001, Peoples R China
[4] Zhengzhou Univ, Key Lab Adv Drug Preparat Technol, Minist Educ, Zhengzhou 450001, Peoples R China
[5] Zhengzhou Univ, Childrens Hosp, Henan Int Joint Lab Prevent & Treatment Pediat Dis, Zhengzhou 450018, Peoples R China
[6] Zhengzhou Univ, Childrens Hosp, Henan Neurodev Engn Res Ctr Children, Zhengzhou 450018, Peoples R China
来源：
PHYTOMEDICINE | 2024年 / 128卷
关键词：
Natural product; Antagonist; Inflammation; ALKEKENGI VAR. FRANCHETII; P2X(7) RECEPTOR; TANSHINONE IIA; SCHISANDRIN-B; IN-VITRO; ASTRAGALUS-MEMBRANACEUS; SCUTELLARIA-BAICALENSIS; INFLAMMATORY RESPONSES; PURINERGIC RECEPTOR; SIGNALING PATHWAY;
D O I：
10.1016/j.phymed.2023.155334
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Background: The P2X7 receptor (P2X7R) is known to play a significant role in regulating various pathological processes associated with immune regulation, neuroprotection, and inflammatory responses. It has emerged as a potential target for the treatment of diseases. In addition to chemically synthesized small molecule compounds, natural products have gained attention as an important source for discovering compounds that act on the P2X7R. Purpose: To explore the research progress made in the field of natural product-derived compounds that act on the P2X7R.
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页数：21
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共 301 条
[1]   CHELATING AND FREE-RADICAL SCAVENGING MECHANISMS OF INHIBITORY-ACTION OF RUTIN AND QUERCETIN IN LIPID-PEROXIDATION [J].
AFANASEV, IB ;
DOROZHKO, AI ;
BRODSKII, AV ;
KOSTYUK, VA ;
POTAPOVITCH, AI .
BIOCHEMICAL PHARMACOLOGY, 1989, 38 (11) :1763-1769
[2]   The P2X7 receptor: Shifting from a low- to a high-conductance channel - An enigmatic phenomenon? [J].
Alves, Luiz Anastacio ;
de Melo Reis, Ricardo Augusto ;
Magalhaes de Souza, Cristina Alves ;
de Freitas, Monica Santos ;
Nogueira Teixeira, Pedro Celso ;
Moreira Ferreira, Dinarte Neto ;
Xavier, Robson Faria .
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, 2014, 1838 (10) :2578-2587
[3]   Pathophysiological Role of Purinergic P2X Receptors in Digestive System Diseases [J].
An, Qimin ;
Yue, Gengyu ;
Yang, Xiaoxu ;
Lou, Jun ;
Shan, Weixi ;
Ding, Jianhong ;
Jin, Zhe ;
Hu, Yanxia ;
Du, Qian ;
Liao, Qiushi ;
Xie, Rui ;
Xu, Jingyu .
FRONTIERS IN PHYSIOLOGY, 2021, 12
[4]   Physalin pool from Physalis angulata L. leaves and physalin D inhibit P2X7 receptor function in vitro and acute lung injury in vivo [J].
Arruda, J. C. C. ;
Rocha, N. C. ;
Santos, E. G. ;
Ferreira, L. G. B. ;
Bello, M. L. ;
Penido, C. ;
Costa, T. E. M. M. ;
Santos, J. A. A. ;
Ribeiro, I. M. ;
Tomassini, T. C. B. ;
Faria, R. X. .
BIOMEDICINE & PHARMACOTHERAPY, 2021, 142
[5]   Anti Diabetetic Activity of Illupai Ver Chooranam on Streptozotocin Diabetic Rats [J].
Azhagarasi, P. ;
Vijayalakshmi, A. ;
Surya, C. ;
Prabha, T. ;
Kiruthiga, N. ;
Kumar, R. Senthil ;
Selvamani, P. ;
Latha, S. .
INTERNATIONAL JOURNAL OF LIFE SCIENCE AND PHARMA RESEARCH, 2022, 12 (03) :L73-L79
[6]   Resveratrol induces apoptosis and cell cycle arrest of human T24 bladder cancer cells in vitro and inhibits tumor growth in vivo [J].
Bai, Yu ;
Mao, Qi-Qi ;
Qin, Jie ;
Zheng, Xiang-Yi ;
Wang, Yun-Bin ;
Yang, Kai ;
Shen, Hua-Feng ;
Xie, Li-Ping .
CANCER SCIENCE, 2010, 101 (02) :488-493
[7]   Antioxidant and antimicrobial properties of bioactive phytochemicals from cranberry [J].
Baranowska, Monika ;
Bartoszek, Agnieszka .
POSTEPY HIGIENY I MEDYCYNY DOSWIADCZALNEJ, 2016, 70 :1460-1468
[8]   A 360° view of the inflammasome: Mechanisms of activation, cell death, and diseases [J].
Barnett, Katherine C. ;
Li, Sirui ;
Liang, Kaixin ;
Ting, Jenny P. -Y. .
CELL, 2023, 186 (11) :2288-2312
[9]   Cranberry Proanthocyanidins Neutralize the Effects of Aggregatibacter actinomycetemcomitans Leukotoxin [J].
Ben Lagha, Amel ;
Howell, Amy ;
Grenier, Daniel .
TOXINS, 2019, 11 (11)
[10]   The P2X7 Receptor Promotes Colorectal Inflammation and Tumorigenesis by Modulating Gut Microbiota and the Inflammasome [J].
Bernardazzi, Claudio ;
Castelo-Branco, Morgana Teixeira Lima ;
Pego, Beatriz ;
Ribeiro, Beatriz Elias ;
Rosas, Siane Lopes Bittencourt ;
Santana, Patricia Teixeira ;
Machado, Joao Carlos ;
Leal, Camille ;
Thompson, Fabiano ;
Coutinho-Silva, Robson ;
de Souza, Heitor Siffert Pereira .
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2022, 23 (09)
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