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CX3CL1/Fractalkine: A Potential Biomarker for Liver Fibrosis in Chronic HBV Infection
被引：0
|作者：
Arsentieva, Natalia A.
[1
]
Korobova, Zoia R.
[1
,2
]
Batsunov, Oleg K.
[1
,2
]
Lyubimova, Natalia E.
[1
]
Basina, Valentina V.
[3
]
Esaulenko, Elena V.
[1
,3
]
Totolian, Areg A.
[1
,2
]
机构：
[1] St Petersburg Pasteur Inst, Lab Mol Immunol, Mira St 14, St Petersburg 197101, Russia
[2] Pavlov First State Med Univ St Petersburg, Dept Immunol, Lva Tolstogo St 6-8, St Petersburg 197022, Russia
[3] St Petersburg State Pediat Med Univ, Dept Infect Dis Adults & Epidemiol, Litovskaya St,Bldg 2, St Petersburg 194100, Russia
关键词：
CX3CL1/Fractalkine;
chemokines;
hepatitis B virus;
hepatitis C virus;
liver fibrosis;
B-VIRUS REPLICATION;
FRACTALKINE RECEPTOR CX(3)CR1;
EXPRESSION;
CONTRIBUTE;
MIGRATION;
DISEASE;
CX3CL1;
CELLS;
D O I：
10.3390/cimb46090593
中图分类号：
Q5 [生物化学];
Q7 [分子生物学];
学科分类号：
071010 ;
081704 ;
摘要：
A hepatitis B virus (HBV) infection can progress to chronic hepatitis, leading to liver fibrosis, cirrhosis, and hepatocellular carcinoma. CX3CL1/Fractalkine plays a crucial role in recruiting immune cells that are responsible for protecting against HBV infection. The aim of this study was to measure CX3CL1/Fractalkine concentrations in the blood plasma of individuals infected with HBV and to evaluate the role of this chemokine in the development of liver tissue fibrosis. Our study included patients infected with HBV, patients infected with HCV, autoimmune hepatitis, and healthy donors. We analyzed the CX3CL1/Fractalkine concentrations in blood plasma using the xMAP technology. Our results showed that HBV-infected patients had lower concentrations of CX3CL1/Fractalkine. Furthermore, in HBV-infected patients with severe fibrosis/cirrhosis, we observed significantly lower concentrations of CX3CL1/Fractalkine compared to those with no/mild fibrosis. Our study revealed that CX3CL1/Fractalkine concentrations are significantly associated with the stage of fibrosis in HBV infection. We demonstrated that lowered CX3CL1/Fractalkine concentrations might have prognostic value for predicting fibrosis development in liver tissue. Our findings suggest that decreased concentrations of CX3CL1/Fractalkine are associated with an increased risk of progressive liver fibrosis, indicating the potential of this chemokine as a prognostic biomarker for the development of liver fibrosis.
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页码：9948 / 9957
页数：10
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