Palladium-Catalyzed Synthesis of Pyrrolo[1,2-α]Pyrazines From N-Phenacyl Pyrrole-2-Carbonitriles and Aryl Boronic Acids

被引：0

作者：

Park, Hyejun ^{[1
]}

Shim, Seunghwan ^{[1
]}

Jeon, Hayoung ^{[2
]}

Lee, Hwayoung ^{[3
]}

Lee, Kiho ^{[2
]}

Lee, Kyeong ^{[3
]}

Lee, Jae Kyun ^{[4
]}

Jalani, Hitesh B. ^{[5
]}

Choi, Yongseok ^{[1
]}

机构：

[1] Korea Univ, Sch Life Sci & Biotechnol, Seoul, South Korea

[2] Korea Univ, Coll Pharm, Sejong, South Korea

[3] Dongguk Univ, Coll Pharm, Goyang, South Korea

[4] Korea Inst Sci & Technol, Ctr Neuromed, Seoul, South Korea

[5] InnovQem Res Lab Pvt Ltd, Ahmadabad, Gujarat, India

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 2024年 / 61卷 / 11期

基金：

新加坡国家研究基金会;

关键词：

aryl boronic acids; carbo-palladation; N-phenacyl pyrrole-2-carbonitriles; pd(TFA)(2); pyrrolo[1,2-alpha]pyrazines; ONE-POT SYNTHESIS; CASCADE REACTIONS; CONCISE; ACCESS; CARBOPALLADATION; CONSTRUCTION; HETEROCYCLES; PYRROLE;

D O I：

10.1002/jhet.4898

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Herein, we have developed palladium-trifluoroacetate-catalyzed carbo-palladation reaction of pyrrole-2-carbonitriles and aryl boronic acids leading to functionally diverse pyrrolo[1,2-alpha]pyrazines under thoroughly optimized reaction conditions. The reaction proceeded smoothly and allowed the diversity-oriented synthesis of pyrrolo[1,2-alpha]pyrazines with broad substrate scope with respect to pyrrole-2-carbonitriles and aryl boronic acids.

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页码：1899 / 1907

页数：9

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