AN ISHLT CONSENSUS STATEMENT ON STRATEGIES TO PREVENT AND MANAGE HEMOCOMPATIBILITY RELATED ADVERSE EVENTS IN PATIENTS WITH A DURABLE, CONTINUOUS-FLOW VENTRICULAR ASSIST DEVICE

被引：3

作者：

Hollis, Ian B. ^{[1
,2
]}

Jennings, Douglas L. ^{[3
]}

Krim, Selim ^{[4
]}

Ton, Van-Khue ^{[5
]}

Ducharme, Anique ^{[6
]}

Cowger, Jennifer ^{[7
]}

Looby, Mary ^{[8
]}

Eulert-Green, J. J. ^{[9
]}

Bansal, Neha ^{[10
]}

Horn, Ed ^{[11
]}

Byku, Mirnela ^{[2
]}

Katz, Jason ^{[12
,13
]}

Michaud, C. J. ^{[14
]}

Rajapreyar, Indranee ^{[15
]}

Campbell, Patrick ^{[16
]}

Vale, Cassandra ^{[17
]}

Cosgrove, Richard ^{[18
]}

Hernandez-Montfort, Jaime ^{[19
]}

Otero, Jessica ^{[20
]}

Ingemi, Amanda ^{[21
]}

Raj, Shashi ^{[22
]}

Weeks, Phillip ^{[23
]}

Agarwal, Richa ^{[24
]}

Martinez, Elena S. ^{[25
]}

Tops, Laurens F. ^{[26
]}

Ahmed, Mustafa M. ^{[27
]}

Kiskaddon, Amy ^{[28
]}

Kremer, Jamila ^{[29
]}

Keebler, Mary ^{[11
]}

Ratnagiri, Ravi K. ^{[30
]}

机构：

[1] Univ N Carolina, Eshelman Sch Pharm, Chapel Hill, NC USA

[2] Univ N Carolina, Med Ctr, Chapel Hill, NC USA

[3] Long Isl Univ, Coll Pharm, New York Presbyterian Columbia Irving Med Ctr, New York, NY USA

[4] John Ochsner Heart & Vasc Inst, New Orleans, LA USA

[5] Massachusetts Gen Hosp, Boston, MA USA

[6] Univ Montreal, Montreal Heart Inst, Montreal, PQ, Canada

[7] Henry Ford Hosp, Detroit, MI USA

[8] Inova Fairfax Med Campus, Falls Church, VA USA

[9] Praxis Wloch, Berlin, Germany

[10] Mt Sinai Kravis Childrens Hosp, New York, NY USA

[11] Univ Pittsburgh, Med Ctr, Pittsburgh, PA USA

[12] NYU, Div Cardiol, Grossman Sch Med, New York, NY USA

[13] Bellevue Hosp, New York, NY USA

[14] Corewell Hlth, Grand Rapids, MI USA

[15] Tufts Med Ctr, Boston, MA USA

[16] Baptist Hlth Med Ctr, Little Rock, AR USA

[17] Prince Charles Hosp, Chermside, Qld, Australia

[18] Univ Arizona, Cornerstone Specialty Hosp, Coll Pharm, Tucson, AZ USA

[19] Baylor Scott & White Hlth Cent Texas & Greater Aus, Temple, TX USA

[20] AdventHlth Littleton Hosp, Littleton, CO USA

[21] Sentara Norfolk Gen Hosp, Norfolk, VA USA

[22] NH Hlth, Bangalore, India

[23] Mem Hermann Texas Med Ctr, Houston, TX USA

[24] Duke Univ, Med Ctr, Durham, NC USA

[25] Cardiovasc Surg Hosp Clin, Barcelona, Spain

[26] Leiden Univ, Med Ctr, Leiden, Netherlands

[27] Univ Florida Hlth, Gainesville, FL USA

[28] Johns Hopkins Univ, Sch Med, Baltimore, MD USA

[29] Univ Hosp Heidelberg, Heidelberg, Germany

[30] MGM Healthcare, Chennai, India

来源：

JOURNAL OF HEART AND LUNG TRANSPLANTATION | 2024年 / 43卷 / 08期

关键词：

hemocompatibility; continuous-flow ventricular assist device; thrombosis; hemorrhage; vitamin K antagonists; antiplatelet medications; anticoagulation; PROTHROMBIN COMPLEX CONCENTRATE; MECHANICAL CIRCULATORY SUPPORT; HEPARIN-INDUCED THROMBOCYTOPENIA; PARTIAL THROMBOPLASTIN TIME; ANTI-FACTOR XA; REDUCES BLOOD REQUIREMENTS; HEALTH-CARE PROFESSIONALS; VON-WILLEBRAND SYNDROME; ACUTE ISCHEMIC-STROKE; HEARTMATE II PATIENTS;

D O I：

10.1016/j.healun.2024.04.065

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Life expectancy of patients with a durable, continuous-flow left ventricular assist device (CF-LVAD) continues to increase. Despite significant improvements in the delivery of care for patients with these devices, hemocompatability-related adverse events (HRAEs) are still a concern and contribute to significant morbility and mortality when they occur. As such, dissemination of current best evidence and practices is of critical importance. This ISHLT Consensus Statement is a summative assessment of the current literature on prevention and management of HRAEs through optimal management of oral anticoagulant and antiplatelet medications, parenteral anticoagulant medications, management of patients at high risk for HRAEs and those experiencing thrombotic or bleeding events, and device management outside of antithrombotic medications. This document is intended to assist clinicians caring for patients with a CF-LVAD provide the best care possible with respect to prevention and management of these events. J Heart Lung Transplant 2024;43:1199-1234 (c) 2024 International Society for Heart and Lung Transplantation. All rights are reserved, including those for text and data mining, AI training, and similar technologies.

引用

页码：1199 / 1234

页数：36

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